PMID- 17982232
OWN - NLM
STAT- MEDLINE
DCOM- 20080110
LR  - 20211020
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 22
IP  - 5
DP  - 2007 Oct
TI  - The combination of tiotropium and budesonide in the treatment of chronic 
      obstructive pulmonary disease.
PG  - 839-45
AB  - Because additive effects of inhaled corticosteroids and long-acting 
      anticholinergics are unclear, we undertook this study to compare the efficacy of 
      tiotropium alone and tiotropium plus budesonide in patients with chronic 
      obstructive pulmonary disease. The study subjects were randomized to receive 
      either tiotropium 18 microg once daily with or without budesonide 200 microg 
      twice daily for 6 weeks. The efficacy variables were changes in trough forced 
      expiratory volume in one second (FEV1), St. George's Respiratory Questionnaire 
      (SGRQ), 6-minute walk distance (6MWD), and use of rescue medication. One hundred 
      patients were randomized and 81 completed the study. The mean age was 64.0 yr, 
      and the mean FEV1 was 39.7% predicted. Compared with tiotropium alone (N=40), the 
      tiotropium/budesonide combination (N=41) was related to an improvement in the 
      SGRQ total score (tiotropium -2.8 units and tiotropium/budesonide -5.6 units, 
      p=0.003). 6MWD was improved by 13.5 m in the tiotropium group and by 22.5 m in 
      the tiotropium/budesonide group (p=0.031). Changes in trough FEV1 and the use of 
      rescue medication were similar between two groups. In conclusion, compared with 
      tiotropium alone, the tiotropium/budesonide combination was related to an 
      improved health-related quality of life. These data support that low-dose 
      budesonide may enhance the efficacy of tiotropium.
FAU - Um, Sang-Won
AU  - Um SW
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Seoul National University College of Medicine, Seoul, Korea.
FAU - Yoo, Chul-Gyu
AU  - Yoo CG
FAU - Kim, Young Whan
AU  - Kim YW
FAU - Han, Sung Koo
AU  - Han SK
FAU - Shim, Young-Soo
AU  - Shim YS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Scopolamine Derivatives)
RN  - 51333-22-3 (Budesonide)
RN  - XX112XZP0J (Tiotropium Bromide)
SB  - IM
MH  - Aged
MH  - Bronchodilator Agents/*administration & dosage
MH  - Budesonide/*administration & dosage
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
MH  - Quality of Life
MH  - Scopolamine Derivatives/*administration & dosage
MH  - Spirometry/methods
MH  - Surveys and Questionnaires
MH  - Tiotropium Bromide
MH  - Treatment Outcome
PMC - PMC2693850
EDAT- 2007/11/06 09:00
MHDA- 2008/01/11 09:00
PMCR- 2007/10/01
CRDT- 2007/11/06 09:00
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2008/01/11 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
PHST- 2007/10/01 00:00 [pmc-release]
AID - 200710839 [pii]
AID - 10.3346/jkms.2007.22.5.839 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2007 Oct;22(5):839-45. doi: 10.3346/jkms.2007.22.5.839.