PMID- 17982598
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20211020
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 7
DP  - 2007 Nov 2
TI  - Effects of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) on sleep and circadian 
      rhythms.
PG  - 231-8
AB  - Abuse of stimulant drugs invariably leads to a disruption in sleep-wake patterns 
      by virtue of the arousing and sleep-preventing effects of these drugs. Certain 
      stimulants, such as 3,4-methylenedioxymethamphetamine (MDMA), may also have the 
      potential to produce persistent alterations in circadian regulation and sleep 
      because they can be neurotoxic toward brain monoaminergic neurons involved in 
      normal sleep regulation. In particular, MDMA has been found to damage brain 
      serotonin (5-HT) neurons in a variety of animal species, including nonhuman 
      primates, with growing evidence that humans are also susceptible to MDMA-induced 
      brain 5-HT neurotoxicity. 5-HT is an important modulator of sleep and circadian 
      rhythms and, therefore, individuals who sustain MDMA-induced 5-HT neurotoxicity 
      may be at risk for developing chronic abnormalities in sleep and circadian 
      patterns. In turn, such abnormalities could play a significant role in other 
      alterations reported in abstinent in MDMA users (e.g., memory disturbance). This 
      paper will review preclinical and clinical studies that have explored the effects 
      of prior MDMA exposure on sleep, circadian activity, and the circadian pacemaker, 
      and will highlight current gaps in knowledge and suggest areas for future 
      research.
FAU - McCann, Una D
AU  - McCann UD
AD  - Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of 
      Medicine, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Drive, 
      Baltimore, MD 21224, USA. umccann@jhmi.edu
FAU - Ricaurte, George A
AU  - Ricaurte GA
LA  - eng
GR  - DA01796401/DA/NIDA NIH HHS/United States
GR  - DA05707/DA/NIDA NIH HHS/United States
GR  - DA05938/DA/NIDA NIH HHS/United States
GR  - HL071501/HL/NHLBI NIH HHS/United States
GR  - M01RR002719/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20071102
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Circadian Rhythm/*drug effects
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/drug effects
MH  - Serotonin/metabolism
MH  - Sleep/*drug effects
MH  - Substance-Related Disorders
PMC - PMC5901258
EDAT- 2007/11/06 09:00
MHDA- 2007/12/07 09:00
PMCR- 2007/11/02
CRDT- 2007/11/06 09:00
PHST- 2007/11/06 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/11/06 09:00 [entrez]
PHST- 2007/11/02 00:00 [pmc-release]
AID - 159317 [pii]
AID - 10.1100/tsw.2007.214 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2007 Nov 2;7:231-8. doi: 10.1100/tsw.2007.214.