PMID- 17983584
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20211020
IS  - 1550-4131 (Print)
IS  - 1550-4131 (Linking)
VI  - 6
IP  - 5
DP  - 2007 Nov
TI  - JNK1 in hematopoietically derived cells contributes to diet-induced inflammation 
      and insulin resistance without affecting obesity.
PG  - 386-97
AB  - Obesity-induced insulin resistance is a major factor in the etiology of type 2 
      diabetes, and Jun kinases (JNKs) are key negative regulators of insulin 
      sensitivity in the obese state. Activation of JNKs (mainly JNK1) in insulin 
      target cells results in phosphorylation of insulin receptor substrates (IRSs) at 
      serine and threonine residues that inhibit insulin signaling. JNK1 activation is 
      also required for accumulation of visceral fat. Here we used reciprocal adoptive 
      transfer experiments to determine whether JNK1 in myeloid cells, such as 
      macrophages, also contributes to insulin resistance and central adiposity. Our 
      results show that deletion of Jnk1 in the nonhematopoietic compartment protects 
      mice from high-fat diet (HFD)-induced insulin resistance, in part through 
      decreased adiposity. By contrast, Jnk1 removal from hematopoietic cells has no 
      effect on adiposity but confers protection against HFD-induced insulin resistance 
      by decreasing obesity-induced inflammation.
FAU - Solinas, Giovanni
AU  - Solinas G
AD  - Department of Medicine, University of Fribourg, Chemin du Musee 5, CH-1700 
      Fribourg, Switzerland.
FAU - Vilcu, Cristian
AU  - Vilcu C
FAU - Neels, Jaap G
AU  - Neels JG
FAU - Bandyopadhyay, Gautam K
AU  - Bandyopadhyay GK
FAU - Luo, Jun-Li
AU  - Luo JL
FAU - Naugler, Willscott
AU  - Naugler W
FAU - Grivennikov, Sergei
AU  - Grivennikov S
FAU - Wynshaw-Boris, Anthony
AU  - Wynshaw-Boris A
FAU - Scadeng, Miriam
AU  - Scadeng M
FAU - Olefsky, Jerrold M
AU  - Olefsky JM
FAU - Karin, Michael
AU  - Karin M
LA  - eng
GR  - DK033651/DK/NIDDK NIH HHS/United States
GR  - ES006376/ES/NIEHS NIH HHS/United States
GR  - ES004151/ES/NIEHS NIH HHS/United States
GR  - T32 DK007202/DK/NIDDK NIH HHS/United States
GR  - DK074868/DK/NIDDK NIH HHS/United States
GR  - R01 ES006376/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cell Metab
JT  - Cell metabolism
JID - 101233170
RN  - 0 (Cytokines)
RN  - 0 (Dietary Fats)
RN  - 0 (Interleukin-6)
RN  - 0 (Palmitates)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dietary Fats/administration & dosage
MH  - Energy Metabolism
MH  - Flow Cytometry
MH  - Hematopoietic Stem Cells/enzymology/*metabolism
MH  - Inflammation/chemically induced/*metabolism/physiopathology
MH  - Insulin Resistance
MH  - Interleukin-6/metabolism
MH  - JNK Mitogen-Activated Protein Kinases/genetics/*metabolism
MH  - Macrophages/cytology/drug effects/metabolism
MH  - Magnetic Resonance Imaging
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Models, Biological
MH  - Obesity/chemically induced/metabolism/physiopathology
MH  - Palmitates/pharmacology
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2007/11/07 09:00
MHDA- 2008/02/27 09:00
CRDT- 2007/11/07 09:00
PHST- 2007/06/12 00:00 [received]
PHST- 2007/08/21 00:00 [revised]
PHST- 2007/09/26 00:00 [accepted]
PHST- 2007/11/07 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/11/07 09:00 [entrez]
AID - S1550-4131(07)00292-6 [pii]
AID - 10.1016/j.cmet.2007.09.011 [doi]
PST - ppublish
SO  - Cell Metab. 2007 Nov;6(5):386-97. doi: 10.1016/j.cmet.2007.09.011.