PMID- 17985091
OWN - NLM
STAT- MEDLINE
DCOM- 20080304
LR  - 20220716
IS  - 0043-5325 (Print)
IS  - 0043-5325 (Linking)
VI  - 119
IP  - 19-20
DP  - 2007
TI  - Gastrinoma--morphological aspects.
PG  - 579-84
AB  - Gastrinomas are defined as gastrin producing tumors that are associated with an 
      elevated fasting gastrin serum level, a positive gastrin secretin stimulation 
      test and certain clinical symptoms, e.g. recurrent peptic ulcer disease and 
      occasionally diarrhea, the so-called Zollinger-Ellison syndrome. Most gastrinomas 
      occur in the duodenum (approx. 70%) and not in the pancreas. The duodenal 
      gastrinomas are small, and when they occur in association with the genetic 
      syndrome of multiple endocrine neoplasia type 1 (MEN1), they are multicentric and 
      originate from precursor lesions. The prognosis of duodenal gastrinomas is better 
      than that of pancreatic gastrinomas, since despite early lymph node metastasis 
      they progress slowly to liver metastasis.
FAU - Kloppel, Gunter
AU  - Kloppel G
AD  - Department of Pathology, University of Kiel, Kiel, Germany. 
      guenterkloeppel@path.uni-kiel.de
FAU - Anlauf, Martin
AU  - Anlauf M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
RN  - 0 (Gastrins)
SB  - IM
MH  - Duodenal Neoplasms/*pathology
MH  - Duodenum/pathology
MH  - Gastrin-Secreting Cells/pathology
MH  - Gastrinoma/*pathology
MH  - Gastrins/*blood
MH  - Humans
MH  - Hyperplasia
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/pathology
MH  - Pancreas/pathology
MH  - Pancreatic Neoplasms/*pathology
MH  - Zollinger-Ellison Syndrome/*pathology
RF  - 40
EDAT- 2007/11/07 09:00
MHDA- 2008/03/05 09:00
CRDT- 2007/11/07 09:00
PHST- 2007/11/07 09:00 [pubmed]
PHST- 2008/03/05 09:00 [medline]
PHST- 2007/11/07 09:00 [entrez]
AID - 10.1007/s00508-007-0885-1 [doi]
PST - ppublish
SO  - Wien Klin Wochenschr. 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1.