PMID- 17985963
OWN - NLM
STAT- MEDLINE
DCOM- 20080108
LR  - 20071107
IS  - 1096-6218 (Print)
IS  - 1557-7740 (Linking)
VI  - 10
IP  - 5
DP  - 2007 Oct
TI  - Clinically important improvement in the intensity of fatigue in patients with 
      advanced cancer.
PG  - 1068-75
AB  - Cancer-related fatigue (CRF) is the most common symptom experienced by patients 
      with cancer. Clinically important improvement in the intensity of fatigue in 
      palliative care patients has not been well established. We reviewed the data from 
      3 clinical trials of fatigue in 194 patients receiving palliative care treatment. 
      Patients completed the Functional Assessment for Chronic Illness Therapy Fatigue 
      (FACIT-F) and Edmonton Symptom Assessment System (ESAS) at baseline and day 8 and 
      their global perception of fatigue improvement (Global benefit score [GBS]: 1 = 
      not beneficial, 7 = greatly important] during day 8. A GBS of 4 or more (moderate 
      improvement, consistently beneficial) was considered a clinically significant 
      improvement. Change scores in the ESAS and FACIT-F from baseline to day 8 were 
      compared to the GBS greater than 4. Receiver-operating characteristic curves were 
      also derived for ESAS and FACIT-F change scores for a GBS greater than 4, greater 
      than 5, and greater than 6. Results showed the mean patient age was 56 (+/-12) 
      years, and 37% were men. A reduction of approximately 10 points in FACIT-F 
      (sensitivity = 73%, specificity = 78%, area under the curve = 0.82) and 4 points 
      in ESAS fatigue (sensitivity = 66%, specificity = 72%, area under the curve = 
      0.78) score was best able to predict a clinically important improvement (GBS >/= 
      4). We were able to characterize the relationship between FACIT-F and ESAS scores 
      and patients' global perception of improvement but further studies are needed to 
      validate our findings.
FAU - Reddy, Shantan
AU  - Reddy S
AD  - Department of Palliative Care and Rehabilitation Medicine, University of Texas M. 
      D. Anderson Cancer Center, Houston, Texas 77030, USA. ebruera@mdanderson.org
FAU - Bruera, Eduardo
AU  - Bruera E
FAU - Pace, Ellen
AU  - Pace E
FAU - Zhang, Karen
AU  - Zhang K
FAU - Reyes-Gibby, Cielito C
AU  - Reyes-Gibby CC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Disease Progression
MH  - Fatigue/drug therapy/*etiology/physiopathology
MH  - Female
MH  - Health Status Indicators
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications/physiopathology
MH  - *Palliative Care
MH  - Psychological Tests
MH  - Psychometrics
MH  - Quality of Life
MH  - ROC Curve
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2007/11/08 09:00
MHDA- 2008/01/09 09:00
CRDT- 2007/11/08 09:00
PHST- 2007/11/08 09:00 [pubmed]
PHST- 2008/01/09 09:00 [medline]
PHST- 2007/11/08 09:00 [entrez]
AID - 10.1089/jpm.2007.0007 [doi]
PST - ppublish
SO  - J Palliat Med. 2007 Oct;10(5):1068-75. doi: 10.1089/jpm.2007.0007.