PMID- 17989282
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 27
IP  - 45
DP  - 2007 Nov 7
TI  - The neuropeptide VGF produces antidepressant-like behavioral effects and enhances 
      proliferation in the hippocampus.
PG  - 12156-67
AB  - Brain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by 
      antidepressant treatments, and BDNF produces antidepressant-like effects in 
      behavioral models of depression. In our previous work, we identified genes 
      induced by BDNF and defined their specific roles in hippocampal neuronal 
      development and plasticity. To identify genes downstream of BDNF that may play 
      roles in psychiatric disorders, we examined a subset of BDNF-induced genes also 
      regulated by 5-HT (serotonin), which includes the neuropeptide VGF 
      (nonacronymic). To explore the function of VGF in depression, we first 
      investigated the expression of the neuropeptide in animal models of depression. 
      VGF was downregulated in the hippocampus after both the learned helplessness and 
      forced swim test (FST) paradigms. Conversely, VGF infusion in the hippocampus of 
      mice subjected to FST reduced the time spent immobile for up to 6 d, thus 
      demonstrating a novel role for VGF as an antidepressant-like agent. Recent 
      evidence indicates that chronic treatment of rodents with antidepressants 
      increases neurogenesis in the adult dentate gyrus and that neurogenesis is 
      required for the behavioral effects of antidepressants. Our studies using 
      [(3)H]thymidine and bromodeoxyuridine as markers of DNA synthesis indicate that 
      chronic VGF treatment enhances proliferation of hippocampal progenitor cells both 
      in vitro and in vivo with survival up to 21 d. By double immunocytochemical 
      analysis of hippocampal neurons, we demonstrate that VGF increases the number of 
      dividing cells that express neuronal markers in vitro. Thus, VGF may act 
      downstream of BDNF and exert its effects as an antidepressant-like agent by 
      enhancing neurogenesis in the hippocampus.
FAU - Thakker-Varia, Smita
AU  - Thakker-Varia S
AD  - Department of Neuroscience and Cell Biology, University of Medicine and Dentistry 
      of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 
      08854-5635, USA.
FAU - Krol, Jennifer Jernstedt
AU  - Krol JJ
FAU - Nettleton, Jacob
AU  - Nettleton J
FAU - Bilimoria, Parizad M
AU  - Bilimoria PM
FAU - Bangasser, Debra A
AU  - Bangasser DA
FAU - Shors, Tracey J
AU  - Shors TJ
FAU - Black, Ira B
AU  - Black IB
FAU - Alder, Janet
AU  - Alder J
LA  - eng
GR  - R01 MH059970-05/MH/NIMH NIH HHS/United States
GR  - R01 MH059970-06/MH/NIMH NIH HHS/United States
GR  - R01 MH059970-07/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antidepressive Agents)
RN  - 0 (Neuropeptides)
RN  - 0 (VGF peptide)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage/antagonists & 
      inhibitors/metabolism
MH  - Behavior, Animal/physiology
MH  - Cell Differentiation/physiology
MH  - *Cell Proliferation
MH  - Depressive Disorder/pathology/*therapy
MH  - Down-Regulation/physiology
MH  - Hippocampus/*cytology/metabolism/*physiology
MH  - Male
MH  - Mice
MH  - Neuronal Plasticity/physiology
MH  - Neurons/cytology/physiology
MH  - Neuropeptides/antagonists & inhibitors/biosynthesis/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC3363962
MID - NIHMS310626
EDAT- 2007/11/09 09:00
MHDA- 2007/12/07 09:00
PMCR- 2008/05/07
CRDT- 2007/11/09 09:00
PHST- 2007/11/09 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/11/09 09:00 [entrez]
PHST- 2008/05/07 00:00 [pmc-release]
AID - 27/45/12156 [pii]
AID - 3281026 [pii]
AID - 10.1523/JNEUROSCI.1898-07.2007 [doi]
PST - ppublish
SO  - J Neurosci. 2007 Nov 7;27(45):12156-67. doi: 10.1523/JNEUROSCI.1898-07.2007.