PMID- 17989344
OWN - NLM
STAT- MEDLINE
DCOM- 20080207
LR  - 20211020
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 177
IP  - 3
DP  - 2008 Feb 1
TI  - Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive 
      lung cancer.
PG  - 342-7
AB  - RATIONALE: The development of lung cancer (LC) is accompanied by field changes in 
      the airway mucosa that may have prognostic importance. OBJECTIVES: To compare 
      patients with prevalent LC to control subjects regarding their histologic 
      dysplasia scores and chromosomal aneusomy as measured by fluorescence in situ 
      hybridization (FISH). METHODS: The most advanced bronchial histology lesion was 
      assessed from each of 44 LC cases and 90 cancer-free control subjects using a 
      four-color FISH probe set encompassing the chromosome 6 centromere, 5p15.2, 7p12 
      (epidermal growth factor receptor), and 8q24 v-myc myelocytomatosis viral 
      oncogene homolog (MYC) sequences. Histology grades were coded as dysplasia 
      (moderate or severe) or carcinoma in situ (CIS). MEASUREMENTS AND MAIN RESULTS: 
      CIS was the highest histologic grade for 32 subjects, and dysplasia was the 
      highest grade for 102 subjects (54 moderate, 48 severe). Chromosomal aneusomy was 
      seen in 64% of the LC cases, but in only 31% of the control subjects (odds ratio 
      [OR], 4.68; 95% confidence interval [CI]. 1.97-11.04). Among those with any level 
      of dysplasia, the OR for positive FISH and LC was 2.28 (95% CI, 0.75-6.86). Among 
      those with CIS, the OR for positive FISH and LC was 5.84 (95% CI, 1.31-26.01). 
      CONCLUSIONS: Chromosomal aneusomy is associated with LC. Prospective examination 
      of aneusomy as a precursor lesion that predicts LC is needed.
FAU - Jonsson, Steinn
AU  - Jonsson S
AD  - Department of Medicine/Medical Oncology, University of Colorado Health Sciences 
      Center, Campus Box 6511, Mail Box 8117, Aurora, CO 80045, USA.
FAU - Varella-Garcia, Marileila
AU  - Varella-Garcia M
FAU - Miller, York E
AU  - Miller YE
FAU - Wolf, Holly J
AU  - Wolf HJ
FAU - Byers, Tim
AU  - Byers T
FAU - Braudrick, Sarah
AU  - Braudrick S
FAU - Kiatsimkul, Porntip
AU  - Kiatsimkul P
FAU - Lewis, Marina
AU  - Lewis M
FAU - Kennedy, Timothy C
AU  - Kennedy TC
FAU - Keith, Robert L
AU  - Keith RL
FAU - Bjornsson, Johannes
AU  - Bjornsson J
FAU - McWilliams, Annette
AU  - McWilliams A
FAU - Lam, Stephen
AU  - Lam S
FAU - Hirsch, Fred R
AU  - Hirsch FR
FAU - Franklin, Wilbur A
AU  - Franklin WA
LA  - eng
GR  - P01-CA58187/CA/NCI NIH HHS/United States
GR  - P30-CA46934/CA/NCI NIH HHS/United States
GR  - U01-CA85070/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071107
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Bronchi/cytology/*pathology
MH  - Bronchoscopy
MH  - Carcinoma in Situ/*genetics/pathology
MH  - Case-Control Studies
MH  - *Chromosome Aberrations
MH  - Disease Progression
MH  - Epithelial Cells/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*genetics/*pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Smoking
PMC - PMC2218849
EDAT- 2007/11/09 09:00
MHDA- 2008/02/08 09:00
PMCR- 2009/02/01
CRDT- 2007/11/09 09:00
PHST- 2007/11/09 09:00 [pubmed]
PHST- 2008/02/08 09:00 [medline]
PHST- 2007/11/09 09:00 [entrez]
PHST- 2009/02/01 00:00 [pmc-release]
AID - 200708-1142OC [pii]
AID - ajrccm1773342 [pii]
AID - 10.1164/rccm.200708-1142OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2008 Feb 1;177(3):342-7. doi: 
      10.1164/rccm.200708-1142OC. Epub 2007 Nov 7.