PMID- 17989719
OWN - NLM
STAT- MEDLINE
DCOM- 20080326
LR  - 20220408
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 22
IP  - 2
DP  - 2008 Feb
TI  - Gene expression profiling suggests primary central nervous system lymphomas to be 
      derived from a late germinal center B cell.
PG  - 400-5
AB  - To characterize the molecular origin of primary lymphomas of the central nervous 
      system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by 
      microarray-based gene expression profiling. Comparison of the transcriptional 
      profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated 
      PCNSL (i) to display gene expression patterns most closely related to late 
      germinal center B cells, (ii) to display a gene expression profile similar to 
      systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned 
      to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) 
      subtype of DLBCL.
FAU - Montesinos-Rongen, M
AU  - Montesinos-Rongen M
AD  - Department of Neuropathology, University Hospital of Cologne, Cologne, Germany.
FAU - Brunn, A
AU  - Brunn A
FAU - Bentink, S
AU  - Bentink S
FAU - Basso, K
AU  - Basso K
FAU - Lim, W K
AU  - Lim WK
FAU - Klapper, W
AU  - Klapper W
FAU - Schaller, C
AU  - Schaller C
FAU - Reifenberger, G
AU  - Reifenberger G
FAU - Rubenstein, J
AU  - Rubenstein J
FAU - Wiestler, O D
AU  - Wiestler OD
FAU - Spang, R
AU  - Spang R
FAU - Dalla-Favera, R
AU  - Dalla-Favera R
FAU - Siebert, R
AU  - Siebert R
FAU - Deckert, M
AU  - Deckert M
LA  - eng
GR  - K23 CA100291/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071108
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - B-Lymphocytes/*pathology
MH  - Central Nervous System Neoplasms/*genetics/pathology
MH  - Female
MH  - *Gene Expression Profiling
MH  - Germinal Center/*pathology
MH  - Humans
MH  - Immunocompetence
MH  - Lymphoma/*genetics/pathology
MH  - Lymphoma, Large B-Cell, Diffuse/genetics/pathology
MH  - Male
MH  - Microarray Analysis
MH  - Middle Aged
PMC - PMC6053313
MID - NIHMS612833
EDAT- 2007/11/09 09:00
MHDA- 2008/03/28 09:00
PMCR- 2018/07/19
CRDT- 2007/11/09 09:00
PHST- 2007/11/09 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2007/11/09 09:00 [entrez]
PHST- 2018/07/19 00:00 [pmc-release]
AID - 2405019 [pii]
AID - 10.1038/sj.leu.2405019 [doi]
PST - ppublish
SO  - Leukemia. 2008 Feb;22(2):400-5. doi: 10.1038/sj.leu.2405019. Epub 2007 Nov 8.