PMID- 17990289
OWN - NLM
STAT- MEDLINE
DCOM- 20080708
LR  - 20080424
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 104
IP  - 1
DP  - 2008 May 1
TI  - Gene expression profiling related to the enhanced erythropoiesis in mouse bone 
      marrow cells.
PG  - 295-303
AB  - Peroxiredoxin II knockout (Prdx II(-/-)) mice had a spontaneous phenotype of 
      hemolytic anemia. In this study, we found that Ter-119(+)CD71(+) cells increased 
      in Prdx II(-/-) mice bone marrow (BM) at 8 weeks of age. We examined the 
      differential expression profiles to bone marrow cells (BMCs) between Prdx II(+/+) 
      and Prdx II(-/-) mice using a cDNA microarray. We identified the 136 candidates 
      were differentially expressed a greater twofold increase or decrease than EPO 
      receptor. In this study, we focused on the up-regulated NBPs during 
      erythropoietic differentiation. According to cDNA microarray results, six NBPs 
      except zfp-127 were up-regulated during erythropoiesis in Prdx II(-/-) mice. 
      Among the six candidates, eIF3-p44, hnRNPH1, G3bp, and Zfpm-1 were dramatically 
      increased at day 7 of the in vitro erythropoietic differentiation of human 
      CD34(+) cells. However, DJ-1 and Rbm3 were slightly increased only at day 12. Our 
      results suggest that up-regulated NBPs might be involved during erythropoietic 
      differentiation.
FAU - Yang, Hee-Young
AU  - Yang HY
AD  - Department of Molecular Medicine, Chonnam National University, Gwangju, South 
      Korea.
FAU - Jeong, Dong Kee
AU  - Jeong DK
FAU - Kim, Seok-Ho
AU  - Kim SH
FAU - Chung, Kyoung-Jin
AU  - Chung KJ
FAU - Cho, Eun-Jin
AU  - Cho EJ
FAU - Jin, Cheng Hao
AU  - Jin CH
FAU - Yang, Ung
AU  - Yang U
FAU - Lee, Sang Ryeul
AU  - Lee SR
FAU - Lee, Dong-Seok
AU  - Lee DS
FAU - Lee, Tae-Hoon
AU  - Lee TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Antigens, CD34)
RN  - 0 (Receptors, Erythropoietin)
RN  - EC 1.11.1.15 (PRDX2 protein, human)
RN  - EC 1.11.1.15 (Peroxiredoxins)
SB  - IM
MH  - Anemia, Hemolytic/genetics
MH  - Animals
MH  - Antigens, CD34
MH  - Bone Marrow Cells/physiology
MH  - Erythropoiesis/*genetics
MH  - *Gene Expression Profiling
MH  - *Hematopoietic Stem Cells
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Oligonucleotide Array Sequence Analysis
MH  - Peroxiredoxins/genetics
MH  - Receptors, Erythropoietin
MH  - Up-Regulation
EDAT- 2007/11/09 09:00
MHDA- 2008/07/09 09:00
CRDT- 2007/11/09 09:00
PHST- 2007/11/09 09:00 [pubmed]
PHST- 2008/07/09 09:00 [medline]
PHST- 2007/11/09 09:00 [entrez]
AID - 10.1002/jcb.21620 [doi]
PST - ppublish
SO  - J Cell Biochem. 2008 May 1;104(1):295-303. doi: 10.1002/jcb.21620.