PMID- 17990988
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20071109
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 6
DP  - 2007 Dec
TI  - Severe acute graft-vs-host disease in a patient with acute monocytic leukemia 
      having a recombination event between HLA-A/B loci from a multiple recombinant 
      family.
PG  - 499-505
AB  - Human leukocyte antigen (HLA) recombination, particularly multiple recombinations 
      can produce novel haplotypes, thereby complicating donor-recipient selection and 
      possibly inducing severe graft-vs-host disease (GVHD) after nonfully matched 
      allogeneic hematopoietic stem cell transplantation. Here, we report for the first 
      time that a 30-year-old female acute monocytic leukemia patient with an HLA-A/B 
      recombinant haplotype, who has three unmatched and one HLA-B/DRB1 recombinant 
      haplotype siblings, presented grade IV acute GVHD (aGVHD) after transplantation 
      from a sibling with a single allele only mismatch at the classical HLA-A locus. 
      Furthermore, using a new three-dimensional structure modeling application, we 
      inferred that the structural differences in peptide-binding and T-cell receptor 
      interaction sites can significantly change the immunogenicity of mismatched HLA 
      molecules, potentially one of the main causes of aGVHD.
FAU - Sun, Y
AU  - Sun Y
AD  - Department of Immunology and National Center for Biomedicine Analysis, Beijing 
      307 Hospital Affiliated to Academy of Medical Sciences, Beijing, China.
FAU - Kong, F
AU  - Kong F
FAU - Ren, S
AU  - Ren S
FAU - Yuan, F
AU  - Yuan F
FAU - Liang, F
AU  - Liang F
FAU - Liu, N
AU  - Liu N
FAU - Jin, L
AU  - Jin L
FAU - Xi, Y
AU  - Xi Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Family
MH  - Female
MH  - Graft vs Host Disease/*genetics
MH  - HLA-A Antigens/chemistry/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Leukemia, Monocytic, Acute/*genetics/immunology/therapy
MH  - Models, Molecular
MH  - Pedigree
MH  - Protein Structure, Tertiary
MH  - Recombination, Genetic
MH  - Risk Factors
EDAT- 2007/11/10 09:00
MHDA- 2008/05/16 09:00
CRDT- 2007/11/10 09:00
PHST- 2007/11/10 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2007/11/10 09:00 [entrez]
AID - TAN953 [pii]
AID - 10.1111/j.1399-0039.2007.00953.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Dec;70(6):499-505. doi: 10.1111/j.1399-0039.2007.00953.x.