PMID- 17991697
OWN - NLM
STAT- MEDLINE
DCOM- 20080519
LR  - 20220409
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 586
IP  - 1
DP  - 2008 Jan 1
TI  - Similar metabolic adaptations during exercise after low volume sprint interval 
      and traditional endurance training in humans.
PG  - 151-60
AB  - Low-volume 'sprint' interval training (SIT) stimulates rapid improvements in 
      muscle oxidative capacity that are comparable to levels reached following 
      traditional endurance training (ET) but no study has examined metabolic 
      adaptations during exercise after these different training strategies. We 
      hypothesized that SIT and ET would induce similar adaptations in markers of 
      skeletal muscle carbohydrate (CHO) and lipid metabolism and metabolic control 
      during exercise despite large differences in training volume and time commitment. 
      Active but untrained subjects (23 +/- 1 years) performed a constant-load cycling 
      challenge (1 h at 65% of peak oxygen uptake (.VO(2peak)) before and after 6 weeks 
      of either SIT or ET (n = 5 men and 5 women per group). SIT consisted of four to 
      six repeats of a 30 s 'all out' Wingate Test (mean power output approximately 500 
      W) with 4.5 min recovery between repeats, 3 days per week. ET consisted of 40-60 
      min of continuous cycling at a workload that elicited approximately 65% (mean 
      power output approximately 150 W) per day, 5 days per week. Weekly time 
      commitment (approximately 1.5 versus approximately 4.5 h) and total training 
      volume (approximately 225 versus approximately 2250 kJ week(-1)) were 
      substantially lower in SIT versus ET. Despite these differences, both protocols 
      induced similar increases (P < 0.05) in mitochondrial markers for skeletal muscle 
      CHO (pyruvate dehydrogenase E1alpha protein content) and lipid oxidation 
      (3-hydroxyacyl CoA dehydrogenase maximal activity) and protein content of 
      peroxisome proliferator-activated receptor-gamma coactivator-1alpha. Glycogen and 
      phosphocreatine utilization during exercise were reduced after training, and 
      calculated rates of whole-body CHO and lipid oxidation were decreased and 
      increased, respectively, with no differences between groups (all main effects, P 
      < 0.05). Given the markedly lower training volume in the SIT group, these data 
      suggest that high-intensity interval training is a time-efficient strategy to 
      increase skeletal muscle oxidative capacity and induce specific metabolic 
      adaptations during exercise that are comparable to traditional ET.
FAU - Burgomaster, Kirsten A
AU  - Burgomaster KA
AD  - Exercise Metabolism Research Group, Department of Kinesiology, McMaster 
      University, Hamilton, Ontario, Canada.
FAU - Howarth, Krista R
AU  - Howarth KR
FAU - Phillips, Stuart M
AU  - Phillips SM
FAU - Rakobowchuk, Mark
AU  - Rakobowchuk M
FAU - Macdonald, Maureen J
AU  - Macdonald MJ
FAU - McGee, Sean L
AU  - McGee SL
FAU - Gibala, Martin J
AU  - Gibala MJ
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071108
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Transcription Factors)
SB  - IM
CIN - J Physiol. 2008 Jan 1;586(1):1-2. PMID: 18167367
MH  - Adaptation, Biological/*physiology
MH  - Adult
MH  - Biopsy
MH  - Carbohydrate Metabolism/physiology
MH  - Energy Metabolism/*physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Heat-Shock Proteins/metabolism
MH  - Humans
MH  - Lipid Metabolism/physiology
MH  - Male
MH  - Muscle, Skeletal/enzymology/pathology
MH  - Oxygen Consumption/physiology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Physical Endurance/*physiology
MH  - Time Factors
MH  - Transcription Factors/metabolism
PMC - PMC2375551
EDAT- 2007/11/10 09:00
MHDA- 2008/05/20 09:00
PMCR- 2009/01/01
CRDT- 2007/11/10 09:00
PHST- 2007/11/10 09:00 [pubmed]
PHST- 2008/05/20 09:00 [medline]
PHST- 2007/11/10 09:00 [entrez]
PHST- 2009/01/01 00:00 [pmc-release]
AID - jphysiol.2007.142109 [pii]
AID - 10.1113/jphysiol.2007.142109 [doi]
PST - ppublish
SO  - J Physiol. 2008 Jan 1;586(1):151-60. doi: 10.1113/jphysiol.2007.142109. Epub 2007 
      Nov 8.