PMID- 17991723
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20161124
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 149
IP  - 2
DP  - 2008 Feb
TI  - Life-long caloric restriction reveals biphasic and dimorphic effects on bone 
      metabolism in rodents.
PG  - 634-41
AB  - Caloric restriction (CR) extends the lifespan of various organisms and slows the 
      onset of age-related disorders; however, little is known about the long-term 
      effects of CR per se on bone. In the present study, we have examined the effects 
      of life-long CR vs. ad libitum (AD) feeding, mainly on the trabecular bone of 
      proximal tibiae in male C57BL/6 mice and F344 rats. Micro-computed tomography 
      scanning of tibiae revealed that CR for 3-9 months caused a substantial decrease 
      in three-dimensional bone volume with structural derangements. Bone 
      histomorphometry revealed the reduced bone mass was due mainly to suppression of 
      bone formation. In db/db mice with defective leptin receptor, CR was unable to 
      decrease bone mass and suppress bone formation. The effect of CR on bone mass was 
      inhibited by administration of a beta-adrenergic blocker, propranolol. Thus, CR 
      may regulate bone formation through leptin signaling and elevated sympathetic 
      nervous tone. Interestingly, the difference in bone volume between the CR and AD 
      groups disappeared after 1 yr of age, and mice and rats on an additional 
      extension of CR to natural death maintained higher bone mass than the AD groups, 
      with reduced bone turnover, suggesting that CR slows skeletal aging by regulating 
      the rate of bone turnover. This is the first report, to our knowledge, that has 
      examined the effects of lifelong CR on bone metabolism and trabecular 
      microstructure and documents its contrasting effects during maturation vs. the 
      postmaturational, involutional period.
FAU - Tatsumi, Sawako
AU  - Tatsumi S
AD  - Department of Bone and Joint Disease, Research Institute, National Center for 
      Geriatrics and Gerontology (NCGG), Morioka, Obu, Aichi, Japan.
FAU - Ito, Masako
AU  - Ito M
FAU - Asaba, Yutaro
AU  - Asaba Y
FAU - Tsutsumi, Kumi
AU  - Tsutsumi K
FAU - Ikeda, Kyoji
AU  - Ikeda K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071108
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Receptors, Leptin)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Diabetes Mellitus/metabolism
MH  - Eating/physiology
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Mice, Mutant Strains
MH  - Osteogenesis/*physiology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Leptin/genetics/metabolism
MH  - Sympathetic Nervous System/physiology
MH  - Tibia/diagnostic imaging/*metabolism
MH  - Tomography, X-Ray Computed
EDAT- 2007/11/10 09:00
MHDA- 2008/03/28 09:00
CRDT- 2007/11/10 09:00
PHST- 2007/11/10 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2007/11/10 09:00 [entrez]
AID - en.2007-1089 [pii]
AID - 10.1210/en.2007-1089 [doi]
PST - ppublish
SO  - Endocrinology. 2008 Feb;149(2):634-41. doi: 10.1210/en.2007-1089. Epub 2007 Nov 
      8.