PMID- 17992688
OWN - NLM
STAT- MEDLINE
DCOM- 20080321
LR  - 20211020
IS  - 0887-4476 (Print)
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 62
IP  - 2
DP  - 2008 Feb
TI  - (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more 
      than forced swim or isolation in neonatal rats.
PG  - 110-21
AB  - (+)-Methamphetamine (MA) administered on postnatal days (P) 11-15 (four 
      times/day) results in increased corticosterone that overlaps the stress 
      hyporesponsive period (SHRP; P2-14) and leads to later learning and memory 
      deficits. Elevated corticosterone during the SHRP results in neurotrophin changes 
      and long-term effects on learning. We determined whether two known stressors 
      could mimic the effects of MA [10 (mg/kg)/dose] administration in neonatal rats. 
      Stressors were four 15-min sessions of forced swim or isolation (confinement in 
      forced swim tubes without water). Saline and weighed-only controls were included 
      and all five treatments were represented within each litter. Corticosterone in 
      plasma and brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) 
      in neostriatum and hippocampus were examined after one or four treatments on P11 
      or P15 (0.5, 1.75, 6.5, or 24 h after first dose). MA increased corticosterone 
      and BDNF; forced swim and isolation also increased corticosterone, but to a 
      lesser extent than MA, and neither stressor increased BDNF. NGF was unaffected by 
      saline treatment, but there was a minor reduction in NGF in the forced swim group 
      compared with the weighed-only group. The data show that MA is more potent at 
      releasing corticosterone and increasing BDNF than short-term, repeated episodes 
      of forced swim or isolation. The possible relationship between these changes and 
      the long-term cognitive effects of developmental MA administration are discussed.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Grace, Curtis E
AU  - Grace CE
AD  - Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, 
      Ohio 45229-3039, USA.
FAU - Schaefer, Tori L
AU  - Schaefer TL
FAU - Herring, Nicole R
AU  - Herring NR
FAU - Skelton, Matthew R
AU  - Skelton MR
FAU - McCrea, Anne E
AU  - McCrea AE
FAU - Vorhees, Charles V
AU  - Vorhees CV
FAU - Williams, Michael T
AU  - Williams MT
LA  - eng
GR  - K01 DA014269-05/DA/NIDA NIH HHS/United States
GR  - T32 ES007051-33/ES/NIEHS NIH HHS/United States
GR  - DA006733/DA/NIDA NIH HHS/United States
GR  - K01 DA014269/DA/NIDA NIH HHS/United States
GR  - T32 ES007051/ES/NIEHS NIH HHS/United States
GR  - ES07051/ES/NIEHS NIH HHS/United States
GR  - R01 DA006733/DA/NIDA NIH HHS/United States
GR  - DA014269/DA/NIDA NIH HHS/United States
GR  - R01 DA006733-17/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Stimulants/*administration & dosage
MH  - Corticosterone/*blood
MH  - Female
MH  - Male
MH  - Methamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Social Isolation
MH  - Stress, Psychological/blood/etiology/*pathology
MH  - Swimming
MH  - Time Factors
PMC - PMC2744944
MID - NIHMS137150
EDAT- 2007/11/10 09:00
MHDA- 2008/03/22 09:00
PMCR- 2009/09/16
CRDT- 2007/11/10 09:00
PHST- 2007/11/10 09:00 [pubmed]
PHST- 2008/03/22 09:00 [medline]
PHST- 2007/11/10 09:00 [entrez]
PHST- 2009/09/16 00:00 [pmc-release]
AID - 10.1002/syn.20470 [doi]
PST - ppublish
SO  - Synapse. 2008 Feb;62(2):110-21. doi: 10.1002/syn.20470.