PMID- 17993781
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20220224
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 6
IP  - 23
DP  - 2007 Dec 1
TI  - Specific in vivo roles for E2Fs in differentiation and development.
PG  - 2917-27
AB  - E2Fs have been historically considered as key interacting factors for the 
      retinoblastoma (Rb) family of pocket proteins, acting as universal regulators of 
      cell cycle progression. Often exhibiting overlapping function, deregulated E2F 
      activity is thought to cancer or cell death. While early reports hypothesized 
      that E2Fs may be capable of regulating distinct functions beyond proliferation, 
      several recent reports have characterized increasingly diverse, context dependent 
      functions for different E2Fs in vivo, often in what appears to a manner beyond 
      traditional cell cycle regulation. Ironically, many of these new functions are 
      still mediated through the classical cell cycle regulatory Rb family of 
      interacting factors. Here we review the recent advances, focusing on 
      differentiation and development, to emphasize that E2F function is likely more 
      complex than the simple model suggests, capable of exhibiting both specificity of 
      function, and roles beyond cell cycle progression in vivo.
FAU - McClellan, Kelly A
AU  - McClellan KA
AD  - Ottawa Health Research Institute, Department of Cellular & Molecular Medicine, 
      University of Ottawa, Ottawa, Ontario, Canada.
FAU - Slack, Ruth S
AU  - Slack RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070831
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (Chromatin)
RN  - 0 (E2F Transcription Factors)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Animals
MH  - *Cell Cycle
MH  - *Cell Differentiation
MH  - Chromatin
MH  - E2F Transcription Factors/*physiology
MH  - Humans
MH  - Retinoblastoma Protein
RF  - 133
EDAT- 2007/11/13 09:00
MHDA- 2008/02/28 09:00
CRDT- 2007/11/13 09:00
PHST- 2007/11/13 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2007/11/13 09:00 [entrez]
AID - 4997 [pii]
AID - 10.4161/cc.6.23.4997 [doi]
PST - ppublish
SO  - Cell Cycle. 2007 Dec 1;6(23):2917-27. doi: 10.4161/cc.6.23.4997. Epub 2007 Aug 
      31.