PMID- 17994015 OWN - NLM STAT- MEDLINE DCOM- 20080317 LR - 20220510 IS - 1097-6256 (Print) IS - 1097-6256 (Linking) VI - 10 IP - 12 DP - 2007 Dec TI - Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. PG - 1513-4 AB - Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression. FAU - Klein, Matthew E AU - Klein ME AD - Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA. FAU - Lioy, Daniel T AU - Lioy DT FAU - Ma, Lin AU - Ma L FAU - Impey, Soren AU - Impey S FAU - Mandel, Gail AU - Mandel G FAU - Goodman, Richard H AU - Goodman RH LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20071111 PL - United States TA - Nat Neurosci JT - Nature neuroscience JID - 9809671 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Mecp2 protein, mouse) RN - 0 (Methyl-CpG-Binding Protein 2) RN - 0 (MicroRNAs) RN - 0 (Oligonucleotides, Antisense) RN - 0 (RNA, Small Interfering) RN - 0 (Thionucleotides) RN - 147336-22-9 (Green Fluorescent Proteins) RN - 1F7A44V6OU (Colforsin) RN - EC 2.3.1.48 (CREB-Binding Protein) SB - IM MH - Animals MH - Animals, Newborn MH - Brain-Derived Neurotrophic Factor/pharmacology MH - CREB-Binding Protein/*physiology MH - Cells, Cultured MH - Cerebral Cortex/cytology MH - Colforsin/pharmacology MH - Drug Interactions MH - Embryo, Mammalian MH - Gene Expression Regulation, Developmental/*drug effects MH - Green Fluorescent Proteins/biosynthesis/genetics MH - Methyl-CpG-Binding Protein 2/deficiency/*metabolism MH - Mice MH - Mice, Knockout MH - MicroRNAs/antagonists & inhibitors/*pharmacology MH - Neurons/drug effects MH - Oligonucleotides, Antisense/pharmacology MH - RNA, Small Interfering/pharmacology MH - Regulatory Elements, Transcriptional/genetics MH - Thionucleotides/pharmacology EDAT- 2007/11/13 09:00 MHDA- 2008/03/18 09:00 CRDT- 2007/11/13 09:00 PHST- 2007/07/19 00:00 [received] PHST- 2007/10/15 00:00 [accepted] PHST- 2007/11/13 09:00 [pubmed] PHST- 2008/03/18 09:00 [medline] PHST- 2007/11/13 09:00 [entrez] AID - nn2010 [pii] AID - 10.1038/nn2010 [doi] PST - ppublish SO - Nat Neurosci. 2007 Dec;10(12):1513-4. doi: 10.1038/nn2010. Epub 2007 Nov 11.