PMID- 17994224
OWN - NLM
STAT- MEDLINE
DCOM- 20080118
LR  - 20160512
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 390
IP  - 2
DP  - 2008 Jan
TI  - Profiling of 3,4-methylenedioxymethamphetamine by means of high-performance 
      liquid chromatography.
PG  - 715-22
AB  - An impurity-profiling method for 3,4-methylenedioxymethamphetamine (MDMA) is 
      presented. The impurities of interest were extracted by solid-phase extraction 
      (SPE) on Bakerbond C18 spe columns from a weakly alkaline solution (pH 8.5). 
      Development of the extraction conditions covered selection of the buffer for 
      dissolution of the sample and the volume of the eluent used to elute the 
      impurities. An important part of the studies was to optimise the separation 
      conditions, and the simplex method was used for this purpose. Cluster analysis 
      was applied for comparison of samples and its grouping. The developed method was 
      based on the areas of 33 selected peaks corresponding to MDMA impurities. All 
      examined samples were correctly classified into clusters corresponding to the 
      synthetic route.
FAU - Byrska, Bogumila
AU  - Byrska B
AD  - Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland.
FAU - Zuba, Dariusz
AU  - Zuba D
LA  - eng
PT  - Journal Article
DEP - 20071110
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analysis
MH  - Chromatography, High Pressure Liquid/*instrumentation/*methods
MH  - Hydrogen-Ion Concentration
EDAT- 2007/11/13 09:00
MHDA- 2008/01/19 09:00
CRDT- 2007/11/13 09:00
PHST- 2007/09/12 00:00 [received]
PHST- 2007/10/16 00:00 [accepted]
PHST- 2007/10/08 00:00 [revised]
PHST- 2007/11/13 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/11/13 09:00 [entrez]
AID - 10.1007/s00216-007-1709-x [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2008 Jan;390(2):715-22. doi: 10.1007/s00216-007-1709-x. Epub 
      2007 Nov 10.