PMID- 17994429
OWN - NLM
STAT- MEDLINE
DCOM- 20080118
LR  - 20211020
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 13
IP  - 5
DP  - 2007 Oct
TI  - The effect of highly active antiretroviral therapy on outcome of central nervous 
      system herpesviruses infection in Cuban human immunodeficiency virus-infected 
      individuals.
PG  - 446-51
AB  - With the rapid progress in the development of highly active antiretroviral 
      therapy (HAART), the observed patterns in human immunodeficiency virus (HIV) 
      encephalitis has changed, allowing herpesvirus (HV) infection to be controlled. 
      HAART was first administered to HIV patients in Cuba in 2001. Consequently with 
      the aim of investigate the behavior of the HVs causing neurological disorders in 
      this population in the post-HAART era, the authors perform a clinical evaluation 
      by a multiplex nested polymerase chain reaction (PCR) assay for simultaneous 
      detection of human HVs--herpes simplex virus (HSV), varicella-zoster virus (VZV), 
      cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV). 
      The authors studied 241 samples of cerebrospinal fluid (CSF) received at the 
      Sexually Transmitted Diseases Laboratory between 2001 and 2005 inclusive. Of the 
      241 CSF studied, 10.4% resulted positive for HV infections. Of these, 92% of 
      patients were acquired immunodeficiency syndrome (AIDS) individuals at the C3 
      stage. CMV (44%), EBV (28%), and dual-HV (16%) infections were the most important 
      agents identified. The principal clinical manifestations were fever, headache, 
      vomiting, and focal abnormalities; the latter being associated with an increased 
      risk of death. A statistically significant result was observed when central 
      nervous system (CNS) disease evolution was compared between patients who were 
      under HAART against those who were not, before they developed encephalitis. It 
      was therefore concluded that it is more likely that HIV individuals receiving 
      HAART have a better recovery of CNS infections than those who are not receiving 
      it.
FAU - Martinez, Pedro Ariel
AU  - Martinez PA
AD  - Virology Department, Institute of Tropical Medicine Pedro Kouri (IPK), Marianao 
      13, Ciudad Habana, Cuba.
FAU - Diaz, Rene
AU  - Diaz R
FAU - Gonzalez, Daniel
AU  - Gonzalez D
FAU - Oropesa, Lisset
AU  - Oropesa L
FAU - Gonzalez, Ruby
AU  - Gonzalez R
FAU - Perez, Lissette
AU  - Perez L
FAU - Viera, Jenniffer
AU  - Viera J
FAU - Kouri, Vivian
AU  - Kouri V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
SB  - IM
MH  - *Antiretroviral Therapy, Highly Active
MH  - Central Nervous System Diseases/*drug therapy/epidemiology/*virology
MH  - Cuba/epidemiology
MH  - Cytomegalovirus Infections/drug therapy
MH  - DNA, Viral/genetics/isolation & purification
MH  - Herpesviridae Infections/*drug therapy/epidemiology/genetics
MH  - Herpesvirus 1, Human
MH  - Herpesvirus 2, Human
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
EDAT- 2007/11/13 09:00
MHDA- 2008/01/19 09:00
CRDT- 2007/11/13 09:00
PHST- 2007/11/13 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/11/13 09:00 [entrez]
AID - 783776097 [pii]
AID - 10.1080/13550280701510088 [doi]
PST - ppublish
SO  - J Neurovirol. 2007 Oct;13(5):446-51. doi: 10.1080/13550280701510088.