PMID- 17994474
OWN - NLM
STAT- MEDLINE
DCOM- 20080116
LR  - 20131121
IS  - 0095-2990 (Print)
IS  - 0095-2990 (Linking)
VI  - 33
IP  - 6
DP  - 2007
TI  - Diffusion tensor imaging in MDMA users and controls: association with decision 
      making.
PG  - 777-89
AB  - Diffusion Tensor Imaging (DTI) may provide information regarding effects of 
      3,4-methylenedioxymethamphetamine (MDMA) use on brain structure. Twelve MDMA 
      users and 20 healthy controls underwent whole brain DTI data acquisition. 
      Fractional anisotropy (FA), mean diffusivity (D(av)), and longitudinal 
      (lambda(1)) and transverse (lambda(T)) diffusivities were compared between MDMA 
      users and controls in 6 regions of the corpus callosum. MDMA users also completed 
      the Barratt Impulsiveness Scale (BIS), and a subset of subjects completed the 
      Iowa Gambling Task (IGT). Results showed significantly smaller lambda(1) in the 
      rostral body of the corpus callosum in MDMA users, with no differences between 
      groups on lambda(T), FA, or D(av). MDMA users also had a significantly higher BIS 
      nonplanning score and greater preference for disadvantageous choices on the IGT. 
      There was a significant positive correlation between lambda(1) in the rostral 
      body of the corpus callosum and advantageous choices on the IGT. Further research 
      on the etiology of these findings is warranted.
FAU - Moeller, F Gerard
AU  - Moeller FG
AD  - Department of Psychiatry and Behavioral Sciences, University of Texas Health 
      Science Center, Houston, Texas 77030, USA. Frederick.g.moeller@uth.tmc.edu
FAU - Steinberg, Joel L
AU  - Steinberg JL
FAU - Lane, Scott D
AU  - Lane SD
FAU - Buzby, Matthew
AU  - Buzby M
FAU - Swann, Alan C
AU  - Swann AC
FAU - Hasan, Khader M
AU  - Hasan KM
FAU - Kramer, Larry A
AU  - Kramer LA
FAU - Narayana, Ponnada A
AU  - Narayana PA
LA  - eng
GR  - K02DA00403/DA/NIDA NIH HHS/United States
GR  - P50DA009262/DA/NIDA NIH HHS/United States
GR  - R01DA15345/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Am J Drug Alcohol Abuse
JT  - The American journal of drug and alcohol abuse
JID - 7502510
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
CIN - Am J Drug Alcohol Abuse. 2007;33(6):765-7. PMID: 17994472
MH  - Adult
MH  - Amphetamine-Related Disorders/*pathology/*psychology
MH  - Anisotropy
MH  - Corpus Callosum/pathology
MH  - Decision Making/*physiology
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Gambling/psychology
MH  - *Hallucinogens
MH  - Humans
MH  - Impulsive Behavior/pathology/psychology
MH  - Male
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - Psychiatric Status Rating Scales
MH  - Psychological Tests
EDAT- 2007/11/13 09:00
MHDA- 2008/01/17 09:00
CRDT- 2007/11/13 09:00
PHST- 2007/11/13 09:00 [pubmed]
PHST- 2008/01/17 09:00 [medline]
PHST- 2007/11/13 09:00 [entrez]
AID - 783770469 [pii]
AID - 10.1080/00952990701651564 [doi]
PST - ppublish
SO  - Am J Drug Alcohol Abuse. 2007;33(6):777-89. doi: 10.1080/00952990701651564.