PMID- 17997337
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20080414
IS  - 1096-6374 (Print)
IS  - 1096-6374 (Linking)
VI  - 18
IP  - 3
DP  - 2008 Jun
TI  - Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: 
      results of the Study of Health in Pomerania (SHIP).
PG  - 228-37
AB  - OBJECTIVE: Insulin-like growth factor I (IGF-1), which is mostly carried by IGF 
      binding protein 3 (IGFBP-3), mediates endocrine actions of growth hormone and 
      represents an important prognostic factor for systemic diseases. The main 
      objectives of the present study were (1) to calculate age- and sex-specific 
      reference values for serum IGF-1 and IGFBP-3 levels using the Gaussian 
      mean+/-1.96 *standard deviation method and the quantile regression method and (2) 
      to perform a comparison of the results from both statistical methods. DESIGN: 
      Cross-sectional study (Study of Health in Pomerania). The study population 
      included 2499 men and women aged 20-79 years. METHODS: Serum IGF-1 and IGFBP-3 
      levels were determined by chemiluminescence immunoassays. Linear and quantile 
      regressions were performed to calculate age- and sex-related reference ranges. 
      RESULTS: Both statistical methods generated different results: The reference 
      ranges based on linear regression identified 43 (1.7%) subjects with serum IGF-1 
      levels and 99 (4.0%) subjects with serum IGFBP-3 levels outside the reference 
      range. Using quantile regression, 117 (4.7%) or 118 subjects (4.7%) with serum 
      IGF-1 or IGFBP-3 levels outside the range were detected, respectively. 
      CONCLUSION: The present study established age- and sex-specific reference ranges 
      for serum IGF-1 and IGFBP-3 levels. Quantile regression should be preferred to 
      calculate reference ranges because a better concordance to original data is 
      possible due to no distribution assumption are required and the robustness 
      against outliers is given.
FAU - Friedrich, Nele
AU  - Friedrich N
AD  - Institute for Community Medicine, Ernst Moritz Arndt University, 
      Walther-Rathenau-Strasse 48, D-17487 Greifswald, Germany. 
      nele.friedrich@uni-greifswald.de
FAU - Alte, Dietrich
AU  - Alte D
FAU - Volzke, Henry
AU  - Volzke H
FAU - Spilcke-Liss, Elisabeth
AU  - Spilcke-Liss E
FAU - Ludemann, Jan
AU  - Ludemann J
FAU - Lerch, Markus M
AU  - Lerch MM
FAU - Kohlmann, Thomas
AU  - Kohlmann T
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Wallaschofski, Henri
AU  - Wallaschofski H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071107
PL  - Scotland
TA  - Growth Horm IGF Res
JT  - Growth hormone & IGF research : official journal of the Growth Hormone Research 
      Society and the International IGF Research Society
JID - 9814320
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/blood
MH  - Female
MH  - Germany
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Regression Analysis
MH  - Sex Characteristics
EDAT- 2007/11/13 09:00
MHDA- 2008/07/30 09:00
CRDT- 2007/11/13 09:00
PHST- 2007/04/24 00:00 [received]
PHST- 2007/09/25 00:00 [revised]
PHST- 2007/09/27 00:00 [accepted]
PHST- 2007/11/13 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2007/11/13 09:00 [entrez]
AID - S1096-6374(07)00133-5 [pii]
AID - 10.1016/j.ghir.2007.09.005 [doi]
PST - ppublish
SO  - Growth Horm IGF Res. 2008 Jun;18(3):228-37. doi: 10.1016/j.ghir.2007.09.005. Epub 
      2007 Nov 7.