PMID- 17997746
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20071113
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 58
IP  - 6
DP  - 2007 Dec
TI  - Association of killer cell immunoglobulin-like receptor genotypes with 
      susceptibility to endometriosis.
PG  - 481-6
AB  - PROBLEM: Endometriosis is an immune-related chronic inflammatory disease with a 
      polygenic predisposition. The aim of this study was to investigate whether 
      polymorphisms in killer cell immunoglobulin-like receptors (KIRs) is responsible, 
      in part, for genetic susceptibility to endometriosis. METHOD OF STUDY: The KIRs 
      genotype was determined in 186 patients with endometriosis and 165 control women 
      using polymerase chain reaction with sequence-specific primers. RESULTS: The 
      frequency of KIR3DS1 was significantly decreased in patients compared with 
      controls (32% versus 44%, P=0.028). KIR data were analyzed using a model 
      comprised of three large groups, in which a gradient of activation/inhibitory 
      potential derived from the combination of KIR and human leukocyte antigen (HLA) 
      ligand genes was taken into account. The frequency of inhibitory KIRs/HLA-class I 
      combination genotypes was significantly higher in patients than in controls 
      (chi2=6.010, 2 df, P=0.0496). CONCLUSION: Our results suggest that polymorphism 
      in KIRs may be associated with susceptibility for endometriosis.
FAU - Kitawaki, Jo
AU  - Kitawaki J
AD  - Department of Obstetrics and Gynecology, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto, Japan. 
      kitawaki@koto.kpu-m.ac.jp
FAU - Xu, Bing
AU  - Xu B
FAU - Ishihara, Hiroaki
AU  - Ishihara H
FAU - Fukui, Michiaki
AU  - Fukui M
FAU - Hasegawa, Goji
AU  - Hasegawa G
FAU - Nakamura, Naoto
AU  - Nakamura N
FAU - Mizuno, Shigeto
AU  - Mizuno S
FAU - Ohta, Mitsuhiro
AU  - Ohta M
FAU - Obayashi, Hiroshi
AU  - Obayashi H
FAU - Honjo, Hideo
AU  - Honjo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Endometriosis/*genetics/*immunology
MH  - Female
MH  - Genes, MHC Class I/immunology
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics/*immunology
EDAT- 2007/11/14 09:00
MHDA- 2008/03/07 09:00
CRDT- 2007/11/14 09:00
PHST- 2007/11/14 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/11/14 09:00 [entrez]
AID - AJI533 [pii]
AID - 10.1111/j.1600-0897.2007.00533.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2007 Dec;58(6):481-6. doi: 10.1111/j.1600-0897.2007.00533.x.