PMID- 17997938
OWN - NLM
STAT- MEDLINE
DCOM- 20091229
LR  - 20190923
IS  - 1672-1977 (Print)
IS  - 1672-1977 (Linking)
VI  - 5
IP  - 6
DP  - 2007 Nov
TI  - [Modulation of Jianjining Recipe on differential protein expression in rats with 
      experimental autoimmune myasthenia gravis].
PG  - 642-6
AB  - OBJECTIVE: To study the modulation of Jianjining Recipe (JJNR), a traditional 
      Chinese compound herbal medicine for invigorating spleen and kidney on 
      differential protein expression in spleen of rats with experimental autoimmune 
      myasthenia gravis (EAMG). METHODS: EAMG rats were randomly divided into four 
      groups: untreated group, JJNR-treated group, Qiangji Jianli capsule (QJJLC, a 
      traditional Chinese compound herbal medicine)-treated group and prednisolone 
      acetate (PA)-treated group. After therapeutic intervention with the above drugs 
      for four consecutive weeks, the level of differential protein expression was 
      analyzed by two-dimensional electrophoresis and matrix assisted laser 
      desorption/ionization time-of-flight mass spectrometry. RESULTS: Twelve 
      differential proteins were identified by comparing EAMG rats and normal rats. The 
      levels of allograft inflammatory factor-1, peroxiredoxin I and actin-related 
      protein 2/3 complex subunit 5 were significantly regulated by JJNR (P<0.01). 
      These proteins were closely associated with immune response and cell movement. 
      CONCLUSION: The results suggest that there are differential protein expressions 
      between EAMG rats and normal rats. Furthermore, as a Chinese medicine 
      prescription with effect of invigorating spleen and kidney, JJNR can effectively 
      regulate the levels of some EAMG-related protein expression.
FAU - Liu, Ping
AU  - Liu P
AD  - Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 
      200032, China. liuping23@sina.com
FAU - Ding, Xu-feng
AU  - Ding XF
FAU - Zhang, Yi-yi
AU  - Zhang YY
FAU - Qiao, Jian
AU  - Qiao J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Xi Yi Jie He Xue Bao
JT  - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
JID - 101199657
RN  - 0 (Actin-Related Protein 2-3 Complex)
RN  - 0 (Aif1 protein, rat)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Microfilament Proteins)
RN  - EC 1.11.1.15 (Peroxiredoxins)
SB  - IM
MH  - Actin-Related Protein 2-3 Complex/analysis
MH  - Animals
MH  - Calcium-Binding Proteins/*analysis
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Electrophoresis, Gel, Two-Dimensional
MH  - Male
MH  - Microfilament Proteins
MH  - Myasthenia Gravis, Autoimmune, Experimental/*drug therapy/metabolism
MH  - Peroxiredoxins/*analysis
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred Lew
EDAT- 2007/11/14 09:00
MHDA- 2009/12/30 06:00
CRDT- 2007/11/14 09:00
PHST- 2007/11/14 09:00 [pubmed]
PHST- 2009/12/30 06:00 [medline]
PHST- 2007/11/14 09:00 [entrez]
AID - 167219772007060642 [pii]
AID - 10.3736/jcim20070608 [doi]
PST - ppublish
SO  - Zhong Xi Yi Jie He Xue Bao. 2007 Nov;5(6):642-6. doi: 10.3736/jcim20070608.