PMID- 17999125
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20240213
IS  - 1091-255X (Print)
IS  - 1091-255X (Linking)
VI  - 12
IP  - 3
DP  - 2008 Mar
TI  - Primary sclerosing cholangitis: detection of cancer in strictures.
PG  - 420-2
AB  - Primary sclerosing cholangitis (PSC) is a significant risk factor for developing 
      cholangiocarcinoma. Tests currently used to screen patients with PSC include 
      serum tumor markers, invasive biliary imaging and sampling techniques, and 
      noninvasive biliary imaging. The most commonly used serum markers are 
      carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA). Invasive 
      biliary imaging includes endoscopic retrograde cholangiopancreatography (ERCP) 
      and percutaneous transhepatic cholangiography (PTC). In addition to standard 
      cytology, the bile can be tested for CA 19-9 levels, as well as other novel tumor 
      markers. In addition, the brushed cells can be analyzed for chromosomal 
      abnormalities using digital image analysis (DIA) or fluorescence in situ 
      hybridization (FISH). Nonivasive imaging techniques include computed tomography 
      (CT), magnetic resonance cholangiopancreatography (MRCP), and positron emission 
      tomography (PET).
FAU - Schulick, Richard D
AU  - Schulick RD
AD  - Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA. 
      rschulick@jhmi.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20071113
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Bile Duct Neoplasms/epidemiology/*etiology
MH  - *Bile Ducts, Intrahepatic
MH  - Biomarkers, Tumor/analysis
MH  - Cholangiocarcinoma/epidemiology/*etiology
MH  - Cholangiography
MH  - Cholangitis, Sclerosing/*complications
MH  - Constriction, Pathologic
MH  - Humans
MH  - Positron-Emission Tomography
MH  - Tomography, X-Ray Computed
RF  - 11
EDAT- 2007/11/14 09:00
MHDA- 2008/05/16 09:00
CRDT- 2007/11/14 09:00
PHST- 2007/09/04 00:00 [received]
PHST- 2007/09/11 00:00 [accepted]
PHST- 2007/11/14 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2007/11/14 09:00 [entrez]
AID - S1091-255X(23)08343-9 [pii]
AID - 10.1007/s11605-007-0345-2 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2008 Mar;12(3):420-2. doi: 10.1007/s11605-007-0345-2. Epub 
      2007 Nov 13.