PMID- 18001303
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20220318
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 34
IP  - 6
DP  - 2007 Dec
TI  - HLA class II similarities in Iranian Kurds and Azeris.
PG  - 457-63
AB  - The genetic relationship between Kurds and Azeris of Iran was investigated based 
      on human leukocyte antigen (HLA) class II profiles. HLA typing was performed 
      using polymerase chain reaction/restriction fragment-length polymorphism 
      (PCR/RFLP) and PCR/sequence-specific primer (PCR/SSP) methods in 100 Kurds and 
      100 Azeris. DRB1*1103/04, DQA1*0501 and DQB1*0301 were the most common alleles 
      and DRB1*1103/04-DQA1*0501-DQB1*0301 was the most frequent haplotype in both 
      populations. No significant difference was observed in HLA class II allele 
      distribution between these populations except for DQB1*0503 which showed a higher 
      frequency in Kurds. Neighbor-joining tree based on Nei's genetic distances and 
      correspondence analysis according to DRB1, DQA1 and DQB1 allele frequencies 
      showed a strong genetic tie between Kurds and Azeris of Iran. The results of 
      amova revealed no significant difference between these populations and other 
      major ethnic groups of Iran. No close genetic relationship was observed between 
      Azeris of Iran and the people of Turkey or Central Asians. According to the 
      current results, present-day Kurds and Azeris of Iran seem to belong to a common 
      genetic pool.
FAU - Farjadian, S
AU  - Farjadian S
AD  - Immunology Department, Shiraz University of Medical Sciences, Shiraz, Iran. 
      farjadsh@sums.ac.ir
FAU - Ghaderi, A
AU  - Ghaderi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Ethnicity/*genetics
MH  - *Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Iran
EDAT- 2007/11/16 09:00
MHDA- 2008/02/26 09:00
CRDT- 2007/11/16 09:00
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
AID - EJI723 [pii]
AID - 10.1111/j.1744-313X.2007.00723.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2007 Dec;34(6):457-63. doi: 10.1111/j.1744-313X.2007.00723.x.