PMID- 18003725
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 82
IP  - 3
DP  - 2008 Feb
TI  - A novel block to mouse mammary tumor virus infection of lymphocytes in B10.BR 
      mice.
PG  - 1314-22
AB  - Classic studies on C57BL-derived mouse strains showed that they were resistant to 
      mouse mammary tumor virus (MMTV) infection. Although one form of resistance 
      mapped to the major histocompatibility complex (MHC) locus, at least one other, 
      unknown gene was implicated in this resistance. We show here that B10.BR mice, 
      which are derived from C57BL mice but have the same MHC locus (H-2(k)) as 
      susceptible C3H/HeN mice, are resistant to MMTV, and show a lack of virus spread 
      in their lymphoid compartments but not their mammary epithelial cells. Although 
      in vivo virus superantigen (Sag)-mediated activation of T cells was similar in 
      C3H/HeN and B10.BR mice, T cell-dependent B-cell and dendritic cell activation 
      was diminished in the latter. Ex vivo, B10.BR T cells showed a diminished 
      capacity to proliferate in response to the MMTV Sag. The genetic segregation of 
      the resistance phenotype indicated that it maps to a single allele. These data 
      highlight the role of Sag-dependent T-cell responses in MMTV infection and point 
      to a novel mechanism for the resistance of mice to retroviral infection that 
      could lead to a better understanding of the interplay between hosts and 
      pathogens.
FAU - Okeoma, Chioma M
AU  - Okeoma CM
AD  - Department of Microbiology and Abramson Family Cancer Center, University of 
      Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
FAU - Shen, Ming
AU  - Shen M
FAU - Ross, Susan R
AU  - Ross SR
LA  - eng
GR  - R01 CA045954/CA/NCI NIH HHS/United States
GR  - T32 CA009140/CA/NCI NIH HHS/United States
GR  - R01CA45954/CA/NCI NIH HHS/United States
GR  - T32-CA9140/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20071114
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Dendritic Cells/immunology
MH  - Female
MH  - Immunity, Innate/genetics/*physiology
MH  - Lymphocyte Activation
MH  - Lymphocytes/*virology
MH  - Mammary Tumor Virus, Mouse/*growth & development
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Retroviridae Infections/*immunology
MH  - T-Lymphocytes/immunology
PMC - PMC2224452
EDAT- 2007/11/16 09:00
MHDA- 2008/02/06 09:00
PMCR- 2008/06/01
CRDT- 2007/11/16 09:00
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
PHST- 2008/06/01 00:00 [pmc-release]
AID - JVI.01848-07 [pii]
AID - 1848-07 [pii]
AID - 10.1128/JVI.01848-07 [doi]
PST - ppublish
SO  - J Virol. 2008 Feb;82(3):1314-22. doi: 10.1128/JVI.01848-07. Epub 2007 Nov 14.