PMID- 18003766
OWN - NLM
STAT- MEDLINE
DCOM- 20080130
LR  - 20231024
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 3
IP  - 1
DP  - 2008 Jan
TI  - N-acetylcysteine in the prevention of contrast-induced nephropathy.
PG  - 281-7
AB  - BACKGROUND AND OBJECTIVES: Contrast-induced nephropathy (CIN) is a common 
      clinical problem that is growing in importance as an increasing number of tests 
      and procedures that utilize contrast media are performed. DESIGN, SETTING, 
      PARTICIPANTS, AND MEASUREMENTS: The biological and pharmacological properties of 
      n-acetylcysteine (NAC) are reviewed, as well as the current literature relevant 
      to the ability of NAC to prevent CIN. RESULTS: After publication of a seminal 
      study by Tepel et al. in 2000, there has been a surge in interest regarding the 
      ability of NAC to reduce the risk for CIN. Since then a large number of studies, 
      mostly with relatively small sample sizes, have been published. CONCLUSIONS: The 
      results have been remarkably varied with some studies finding great efficacy with 
      NAC but most finding no significant benefit.
FAU - Fishbane, Steven
AU  - Fishbane S
AD  - Winthrop-University Hospital, Mineola, New York 11501, USA. 
      sfishbane@winthrop.org
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20071114
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
RN  - 0 (Contrast Media)
RN  - 0 (Free Radical Scavengers)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/chemistry/*therapeutic use
MH  - Acute Kidney Injury/*chemically induced/*prevention & control
MH  - Contrast Media/*adverse effects
MH  - Free Radical Scavengers/chemistry/*therapeutic use
MH  - Humans
RF  - 80
EDAT- 2007/11/16 09:00
MHDA- 2008/01/31 09:00
CRDT- 2007/11/16 09:00
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/01/31 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
AID - CJN.02590607 [pii]
AID - 10.2215/CJN.02590607 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2008 Jan;3(1):281-7. doi: 10.2215/CJN.02590607. Epub 2007 
      Nov 14.