PMID- 18003791
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20220408
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 294
IP  - 1
DP  - 2008 Jan
TI  - Exercise accelerates cutaneous wound healing and decreases wound inflammation in 
      aged mice.
PG  - R179-84
AB  - The purpose of this study was to determine the effect of exercise on wound 
      healing and inflammation in young (3 mo) and old (18 mo) female BALB/cByJ mice. 
      Mice were assigned to either exercise or sedentary control (control) groups. The 
      exercise group mice were run on a motorized treadmill at a moderate intensity 30 
      min/day for 8 days. All mice were given four full-thickness dermal wounds, and 
      the rate of wound closure was assessed daily for 10 days. Four months later, the 
      aged mice were rerandomized to treatment, wounded again in different locations, 
      and wounds were harvested at 1, 3, or 5 days postwounding. Wound tissue was 
      analyzed for IL-1beta, IL-6, keratinocyte chemoattractant (KC), monocyte 
      chemoattractant protein-1 (MCP-1), and TNF-alpha protein. Myeloperoxidase (MPO) 
      activity and F4/80 mRNA were assessed as an indirect measure of neutrophil and 
      macrophage content, respectively. There was a trend (P = 0.10) for exercise to 
      reduce wound size in young mice, and exercise significantly (P < 0.05) decreased 
      wound size in old mice. TNF-alpha, KC, and MCP-1 were significantly (P < 0.05) 
      lower in wounds from exercised old mice compared with control. No group 
      differences were found for wound IL-1beta or IL-6, MPO activity, or F4/80 mRNA. 
      Our data suggest that exercise accelerates the wound healing process in old mice. 
      This improved healing response in the old mice may be the result of an 
      exercise-induced anti-inflammatory response in the wound.
FAU - Keylock, K Todd
AU  - Keylock KT
AD  - Department of Kinesiology and Community Health, University of Illinois, 
      Urbana-Champaign, Urbana, IL 61801, USA.
FAU - Vieira, Victoria J
AU  - Vieira VJ
FAU - Wallig, Matthew A
AU  - Wallig MA
FAU - DiPietro, Luisa A
AU  - DiPietro LA
FAU - Schrementi, Megan
AU  - Schrementi M
FAU - Woods, Jeffrey A
AU  - Woods JA
LA  - eng
GR  - R01 AG023580/AG/NIA NIH HHS/United States
GR  - R01 GM55238/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071114
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Chemokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (monocyte-macrophage differentiation antigen)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Antigens, Differentiation/metabolism
MH  - Body Weight/physiology
MH  - Chemokines/metabolism
MH  - Eating/physiology
MH  - Female
MH  - Inflammation/physiopathology/*prevention & control
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Peroxidase/metabolism
MH  - Physical Conditioning, Animal/*physiology
MH  - Random Allocation
MH  - Skin/*injuries/metabolism/physiopathology
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Wound Healing/*physiology
EDAT- 2007/11/16 09:00
MHDA- 2008/02/27 09:00
CRDT- 2007/11/16 09:00
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
AID - 00177.2007 [pii]
AID - 10.1152/ajpregu.00177.2007 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R179-84. doi: 
      10.1152/ajpregu.00177.2007. Epub 2007 Nov 14.