PMID- 18004072
OWN - NLM
STAT- MEDLINE
DCOM- 20080414
LR  - 20080319
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 145
IP  - 4
DP  - 2008
TI  - Birth order and cord immunoglobulin E: results using a high-sensitivity 
      immunoglobulin E protocol.
PG  - 305-12
AB  - BACKGROUND: Studies have shown an inverse association between birth order and 
      allergic disease risk; some but not all have shown an inverse association between 
      cord blood immunoglobulin E (IgE) and birth order. We further examined the 
      relationship between birth order and cord blood IgE in a racially diverse birth 
      cohort. METHODS: Women were interviewed about their pregnancy history, and their 
      babies' cord blood was collected to measure total IgE using a high-sensitivity 
      protocol (lower detection limit 0.01 IU/ml). We analyzed cord IgE as both a 
      continuous and categorical measure. RESULTS: Of the 733 children, 171 (23%) were 
      first born, 92 (13%) were first born with the mother having prior pregnancies but 
      no live births, and 470 (64%) were born second or later. By birth order, the 
      geometric means +/- standard deviations were: first born 0.26 +/- 4.2 IU/ml, 
      first born after prior pregnancies 0.35 +/- 3.9 IU/ml, second born 0.30 +/- 4.8 
      IU/ml, third born 0.28 +/- 5.1 IU/ml, and fourth born or greater 0.28 +/- 4.5 
      IU/ml (trend p = 0.51). Other factors considered (maternal allergic disease 
      history, age, race, exposure to smoking and cats/dogs during pregnancy, fetal 
      gender, season of delivery) neither modified nor confounded these relationships. 
      CONCLUSIONS: Unlike some previous reports, there was no association between total 
      cord IgE level and birth order. Mechanisms other than cord IgE should be studied 
      in the quest to understand the role of birth order in allergic disease risk. 
      Categorization of a continuous measure of IgE may incorrectly create 
      statistically significant results.
CI  - 2007 S. Karger AG, Basel
FAU - Wegienka, Ganesa
AU  - Wegienka G
AD  - Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, 
      Detroit, Mich. 48202, USA. gwegien1@hfhs.org
FAU - Havstad, Suzanne
AU  - Havstad S
FAU - Shue, Leo
AU  - Shue L
FAU - Zoratti, Edward
AU  - Zoratti E
FAU - Ownby, Dennis R
AU  - Ownby DR
FAU - Johnson, Christine Cole
AU  - Johnson CC
LA  - eng
PT  - Journal Article
DEP - 20071113
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - *Antibody Specificity
MH  - *Birth Order
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunization/standards
MH  - Immunoglobulin E/*blood
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Pregnancy Complications/immunology
EDAT- 2007/11/16 09:00
MHDA- 2008/04/15 09:00
CRDT- 2007/11/16 09:00
PHST- 2007/01/23 00:00 [received]
PHST- 2007/06/20 00:00 [accepted]
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/04/15 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
AID - 000110889 [pii]
AID - 10.1159/000110889 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2008;145(4):305-12. doi: 10.1159/000110889. Epub 2007 
      Nov 13.