PMID- 18004115
OWN - NLM
STAT- MEDLINE
DCOM- 20080429
LR  - 20071116
IS  - 0954-6928 (Print)
IS  - 0954-6928 (Linking)
VI  - 18
IP  - 8
DP  - 2007 Dec
TI  - Relationship of admission haematological indices with infarct-related artery 
      patency in patients with acute ST-segment elevation myocardial infarction treated 
      with primary angioplasty.
PG  - 639-44
AB  - OBJECTIVE: Mean platelet volume (MPV), a marker for platelet reactivity, and 
      white blood cell count (WBC-C), a marker for inflammation, have been shown to be 
      predictive of unfavourable outcomes among survivors of ST elevation myocardial 
      infarction (STEMI). The relationship of admission MPV and WBC-C with 
      infarct-related artery (IRA) patency is not clear. We aimed to evaluate the value 
      of admission MPV and WBC-C for the prediction of IRA patency, in patients with 
      acute STEMI treated with primary percutaneous coronary intervention. METHODS: 
      Blood samples were obtained on admission in 351 STEMI patients. The patients who 
      had thrombolysis in myocardial infarction (TIMI) 3 flow in initial angiography 
      constituted the IRA patent group and others having less than TIMI 3 flow 
      constituted the IRA occluded group. RESULTS: In 16% of the patients, IRAs were 
      found to be patent on initial angiography. Patients in the IRA occluded group had 
      higher admission MPVs (9.3+/-1.2 vs. 8.6+/-1.3 fl, P<0.001) and higher WBC-C 
      (13.3+/-4.8 vs. 11.0+/-2.9, P=0.002) compared with patients in the patent IRA 
      group. In regression analysis, WBC-Cs [beta, 0.131; odds ratio (OR), 1.140; 95% 
      confidence interval (CI), 1.043-1.245, P=0.004)] and MPV (beta, 0.519; OR, 1.680; 
      95% CI, 1.206-2.339, P=0.002) were found to be independent predictors of occluded 
      IRA. The best cutoff value of MPV for predicting an occluded IRA was determined 
      to be 8.55 fl with a sensitivity of 74% and a specificity of 60%. CONCLUSION: MPV 
      and WBC-C at admission might be valuable in the prediction of IRA patency and in 
      planning the need for adjunctive therapy to improve outcomes in patients with 
      STEMI undergoing percutaneous coronary intervention.
FAU - Maden, Orhan
AU  - Maden O
AD  - Cardiology Department, Yuksek Ihtisas Education and Research Hospital, Ankara, 
      Turkey. dorhanmaden@yahoo.co.uk
FAU - Kacmaz, Fehmi
AU  - Kacmaz F
FAU - Selcuk, Mehmet T
AU  - Selcuk MT
FAU - Selcuk, Hatice
AU  - Selcuk H
FAU - Metin, Fatma
AU  - Metin F
FAU - Tufekcioglu, Omac
AU  - Tufekcioglu O
FAU - Atak, Ramazan
AU  - Atak R
FAU - Balbay, Yucel
AU  - Balbay Y
FAU - Ilkay, Erdogan
AU  - Ilkay E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
SB  - IM
MH  - Aged
MH  - *Angioplasty
MH  - Female
MH  - Humans
MH  - *Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*physiopathology/surgery
MH  - *Patient Admission
MH  - *Vascular Patency
EDAT- 2007/11/16 09:00
MHDA- 2008/04/30 09:00
CRDT- 2007/11/16 09:00
PHST- 2007/11/16 09:00 [pubmed]
PHST- 2008/04/30 09:00 [medline]
PHST- 2007/11/16 09:00 [entrez]
AID - 00019501-200712000-00008 [pii]
AID - 10.1097/MCA.0b013e3282f0eecb [doi]
PST - ppublish
SO  - Coron Artery Dis. 2007 Dec;18(8):639-44. doi: 10.1097/MCA.0b013e3282f0eecb.