PMID- 18005322
OWN - NLM
STAT- MEDLINE
DCOM- 20080328
LR  - 20080130
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 48
IP  - 2
DP  - 2008 Feb
TI  - Human immunodeficiency virus-1 infection correlates strongly with herpes simplex 
      virus-2 (genital herpes) seropositivity in South African and United States blood 
      donations.
PG  - 295-303
AB  - BACKGROUND: In South Africa, human immunodeficiency virus-1 (HIV-1) infection 
      correlates with herpes simplex virus-2 (HSV-2; genital herpes) seropositivity in 
      genitourinary disease clinic attendees. HSV-2 infection may be a marker for risk 
      behavior and/or directly facilitate HIV-1 transmission. The rate of HSV-2 
      infection in HIV-infected South African and US blood donations was assessed, and 
      whether the infections were correlated in donors screened and found negative for 
      high-risk behavior by predonation interview was questioned. STUDY DESIGN AND 
      METHODS: A total of 625 South African and 393 US HIV-1-infected repository 
      samples previously characterized for longstanding or recent HIV-1 infection were 
      tested with two commercially available HSV-2-specific assays. The prevalence of 
      HSV-2 antibodies in South Africa was further assessed in 106 HIV-1-infected and 
      106 HIV-1-negative donors matched for sex, race, and donation history, as well as 
      200 random HIV-1-negative donors. RESULTS: A total of 52.2 percent of US and 69.3 
      percent of South African HIV-1-infected donations were HSV-2-seropositive. Age, 
      race, and sex were independent risk factors for HSV-2 antibody prevalence in 
      HIV-1-infected South African donors, who were more likely to be HSV-2 
      antibody-reactive than random HIV-1-negative donors (72.6% vs. 8.5%: odds ratio 
      [OR], 28.6; 95% confidence interval [CI], 14.5-55) or matched donors (71.6% vs. 
      19.6%: OR, 10.3; 95% CI, 5.4-19.8). HIV-1 infection and HSV-2 seropositivity 
      correlated in white and black populations when analyzed by age group. 
      CONCLUSIONS: HIV-1 infection correlates strongly with HSV-2 seropositivity in US 
      and South African blood donors. Our data describe the characteristics of HSV-2 
      antibody testing as a surrogate marker for HIV-1 infection and support a 
      facilitating role for HSV-2 infection in HIV-1 transmission.
FAU - Benjamin, Richard J
AU  - Benjamin RJ
AD  - Biomedical Services, Medical Office, American Red Cross, Washington, DC 20006, 
      USA. BenjaminR@usa.redcross.org
FAU - Busch, Michael P
AU  - Busch MP
FAU - Fang, Chyang T
AU  - Fang CT
FAU - Notari, Edward P
AU  - Notari EP
FAU - Puren, Adrian
AU  - Puren A
FAU - Schoub, Barry D
AU  - Schoub BD
FAU - Tobler, Leslie H
AU  - Tobler LH
FAU - Hogrefe, Wayne
AU  - Hogrefe W
FAU - du P Heyns, Anthon
AU  - du P Heyns A
FAU - Stramer, Susan L
AU  - Stramer SL
FAU - Crookes, Robert L
AU  - Crookes RL
LA  - eng
PT  - Journal Article
DEP - 20071113
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/immunology
MH  - *Blood Donors
MH  - Female
MH  - HIV Infections/*blood/*virology
MH  - HIV-1/*physiology
MH  - Herpes Genitalis/*blood/*virology
MH  - *Herpesvirus 2, Human/immunology
MH  - Humans
MH  - Male
MH  - South Africa
MH  - Time Factors
EDAT- 2007/11/17 09:00
MHDA- 2008/03/29 09:00
CRDT- 2007/11/17 09:00
PHST- 2007/11/17 09:00 [pubmed]
PHST- 2008/03/29 09:00 [medline]
PHST- 2007/11/17 09:00 [entrez]
AID - TRF01523 [pii]
AID - 10.1111/j.1537-2995.2007.01523.x [doi]
PST - ppublish
SO  - Transfusion. 2008 Feb;48(2):295-303. doi: 10.1111/j.1537-2995.2007.01523.x. Epub 
      2007 Nov 13.