PMID- 18005697
OWN - NLM
STAT- MEDLINE
DCOM- 20071211
LR  - 20220409
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Linking)
VI  - 1
IP  - 3
DP  - 2007 May 17
TI  - A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced 
      immunity in plants.
PG  - 175-85
AB  - Pathogen-associated molecular patterns (PAMPs) elicit basal defense responses in 
      plants, and, in turn, pathogens have evolved mechanisms to overcome these 
      PAMP-induced defenses. To suppress immunity, the phytopathogenic bacterium 
      Pseudomonas syringae secretes effector proteins, the biochemical function and 
      virulence targets of which remain largely unknown. We show that HopAI1, an 
      effector widely conserved in both plant and animal bacterial pathogens, inhibits 
      the Arabidopsis mitogen-activated protein kinases (MAPKs) activated by exposure 
      to PAMPs. HopAI1 inactivates MAPKs by removing the phosphate group from 
      phosphothreonine through a unique phosphothreonine lyase activity, which is 
      required for HopAI1 function. The inhibition of MAPKs by HopA1 suppresses two 
      independent downstream events, namely the reinforcement of cell wall defense and 
      transcriptional activation of PAMP response genes. The MAPKs MPK3 and MPK6 
      physically interact with HopAI1 indicating that they are direct targets of 
      HopAI1. These findings uncover a mechanism by which Pseudomonas syringae 
      overcomes host innate immunity to promote pathogenesis.
FAU - Zhang, Jie
AU  - Zhang J
AD  - National Key Laboratory of Plant Molecular Genetics, Institute of Plant 
      Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, Shanghai 200032, China.
FAU - Shao, Feng
AU  - Shao F
FAU - Li, Yan
AU  - Li Y
FAU - Cui, Haitao
AU  - Cui H
FAU - Chen, Linjie
AU  - Chen L
FAU - Li, Hongtao
AU  - Li H
FAU - Zou, Yan
AU  - Zou Y
FAU - Long, Chengzu
AU  - Long C
FAU - Lan, Lefu
AU  - Lan L
FAU - Chai, Jijie
AU  - Chai J
FAU - Chen, She
AU  - Chen S
FAU - Tang, Xiaoyan
AU  - Tang X
FAU - Zhou, Jian-Min
AU  - Zhou JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Virulence Factors)
RN  - 1114-81-4 (Phosphothreonine)
RN  - 27YLU75U4W (Phosphorus)
RN  - EC 2.7.11.24 (AtMPK3 protein, Arabidopsis)
RN  - EC 2.7.11.24 (MPK6 protein, Arabidopsis)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Arabidopsis
MH  - Arabidopsis Proteins/metabolism
MH  - Bacterial Proteins/immunology/metabolism
MH  - Mitogen-Activated Protein Kinase Kinases/metabolism
MH  - Mitogen-Activated Protein Kinases/*antagonists & inhibitors/metabolism
MH  - Phosphorus/metabolism
MH  - Phosphothreonine/metabolism
MH  - Plant Diseases/*immunology/*microbiology
MH  - Pseudomonas syringae/*immunology/metabolism
MH  - Virulence Factors/immunology/metabolism
EDAT- 2007/11/17 09:00
MHDA- 2007/12/12 09:00
CRDT- 2007/11/17 09:00
PHST- 2006/10/29 00:00 [received]
PHST- 2007/01/28 00:00 [revised]
PHST- 2007/03/05 00:00 [accepted]
PHST- 2007/11/17 09:00 [pubmed]
PHST- 2007/12/12 09:00 [medline]
PHST- 2007/11/17 09:00 [entrez]
AID - S1931-3128(07)00045-5 [pii]
AID - 10.1016/j.chom.2007.03.006 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2007 May 17;1(3):175-85. doi: 10.1016/j.chom.2007.03.006.