PMID- 18006511
OWN - NLM
STAT- MEDLINE
DCOM- 20080221
LR  - 20131121
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Linking)
VI  - 37
IP  - 1
DP  - 2008 Jan
TI  - The association between urinary albumin excretion and ankle-brachial index in 
      elderly Taiwanese patients with type 2 diabetes mellitus.
PG  - 77-82
AB  - OBJECTIVE: this study examined the association between urinary albumin/creatinine 
      ratio (ACR) and ankle-brachial index (ABI), or peripheral arterial disease (PAD), 
      in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: a total of 290 
      (108 men, 182 women) T2DM, aged > or =65 (71.6 +/- 4.9) years were recruited. PAD 
      was diagnosed by ABI<0.9, and ACR was divided into normoalbuminuria (<30.0 
      microg/mg), microalbuminuria (30.0-299.9 microg/mg), and macroalbuminuria (> or = 
      300.0 microg/mg). RESULTS: patients with PAD (n = 45) had higher ln(ACR) than 
      patients without: 4.48 +/- 1.48 versus 3.73 +/- 1.39 (P<0.01). For 
      normoalbuminuria (n = 112), microalbuminuria (n = 152), and macroalbuminuria (n = 
      26), respective PAD prevalence was 8.0, 17.1 and 38.5% (P<0.001). The proportion 
      of normoalbuminuria, microalbuminuria and macroalbuminuria in patients with PAD 
      was 20.0, 57.8 and 22.2%, respectively; and 42.0, 51.4 and 6.5%, respectively, in 
      patients without (P<0.001). Ln(ACR) was inversely correlated with ABI in all 
      patients (gamma = -0.198, P<0.01) and in separate sexes (gamma = -0.211 for men 
      and gamma = -0.181 for women). The multivariate-adjusted odds ratios for PAD for 
      every 1 unit increment of ln(ACR) was 1.66 (1.17-2.34); and for microalbuminuria 
      versus normoalbuminuria and macroalbuminuria versus normoalbuminuria were 2.54 
      (1.05-6.17) and 5.86 (1.76-19.52), respectively. CONCLUSIONS: urinary ACR is not 
      only associated with PAD, it is also significantly correlated with ABI in an 
      inverse pattern in elderly Taiwanese with T2DM.
FAU - Tseng, Chin-Hsiao
AU  - Tseng CH
AD  - Department of Internal Medicine, National Taiwan University College of Medicine, 
      Taipei, Taiwan. ccktsh@ms6.hinet.net
FAU - Chong, Choon-Khim
AU  - Chong CK
FAU - Tseng, Ching-Ping
AU  - Tseng CP
FAU - Tai, Tong-Yuan
AU  - Tai TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071114
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/diagnosis/epidemiology/*physiopathology
MH  - Ankle/blood supply
MH  - Blood Pressure/*physiology
MH  - *Blood Pressure Determination
MH  - Brachial Artery/physiopathology
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*physiopathology
MH  - Diabetic Angiopathies/diagnosis/epidemiology/*physiopathology
MH  - Diabetic Nephropathies/diagnosis/epidemiology/*physiopathology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Ischemia/diagnosis/epidemiology/physiopathology
MH  - Leg/blood supply
MH  - Male
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Taiwan
MH  - Ultrasonography, Doppler
EDAT- 2007/11/17 09:00
MHDA- 2008/02/22 09:00
CRDT- 2007/11/17 09:00
PHST- 2007/11/17 09:00 [pubmed]
PHST- 2008/02/22 09:00 [medline]
PHST- 2007/11/17 09:00 [entrez]
AID - afm148 [pii]
AID - 10.1093/ageing/afm148 [doi]
PST - ppublish
SO  - Age Ageing. 2008 Jan;37(1):77-82. doi: 10.1093/ageing/afm148. Epub 2007 Nov 14.