PMID- 18006938
OWN - NLM
STAT- MEDLINE
DCOM- 20080516
LR  - 20220408
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 16
IP  - 11
DP  - 2007 Nov
TI  - Intra-individual variation of plasma adipokine levels and utility of single 
      measurement of these biomarkers in population-based studies.
PG  - 2464-70
AB  - Adipokines, soluble mediators produced by adipocytes, may link adipose tissue to 
      the inflammatory, metabolic, and immune dysregulation that characterize many 
      obesity-related diseases. The stability of plasma adipokine levels within 
      individuals, their seasonal variability, intercorrelations, and relationships to 
      well-established measures of adiposity are incompletely defined. We measured 
      levels of 12 adipokines [interleukin 1beta (IL-1beta), IL-6, IL-8, tumor necrosis 
      factor-alpha (TNF-alpha), plasminogen activator inhibitor-1 (PAI-1), 
      high-sensitivity C-reactive protein (hsCRP), monocyte chemoattractant protein-1 
      (MCP-1), nerve growth factor (NGF), leptin, adiponectin, hepatocyte growth factor 
      (HGF), and resistin] in four seasonal random plasma samples of 48 male 
      participants of a population-based cohort study. The representativeness of single 
      measurements was assessed by correlating the adipokine levels of a single, random 
      sample with the mean levels from the remaining three samples using a bootstrap 
      approach and using intra-class correlation coefficients (ICC). Spearman 
      correlations between adipokine levels, age, body mass index (BMI), and 
      waist-to-hip ratio (WHR) were estimated. Correlations between plasma adipokine 
      levels from one random sample and the mean of the remaining three seasonal 
      samples ranged from 0.57 to 0.89. Over the 1-year study period, the ICCs for 
      adipokine levels ranged from 0.44 (PAI-1) to 0.83 (HGF). IL-8, MCP-1, and 
      resistin levels were positively associated with age; HGF and PAI-1 levels were 
      correlated with BMI and WHR. This study suggests that adipokine levels in a 
      single blood sample may be useful biomarkers of inflammation in population-based 
      studies of obesity-related disease.
FAU - Lee, Sang-Ah
AU  - Lee SA
AD  - Vanderbilt Epidemiology Center, Nashville, Tennessee 37203-1738, USA.
FAU - Kallianpur, Asha
AU  - Kallianpur A
FAU - Xiang, Yong-Bing
AU  - Xiang YB
FAU - Wen, Wanqing
AU  - Wen W
FAU - Cai, Qiuyin
AU  - Cai Q
FAU - Liu, Dake
AU  - Liu D
FAU - Fazio, Sergio
AU  - Fazio S
FAU - Linton, MacRae F
AU  - Linton MF
FAU - Zheng, Wei
AU  - Zheng W
FAU - Shu, Xiao Ou
AU  - Shu XO
LA  - eng
GR  - R01 CA082729/CA/NCI NIH HHS/United States
GR  - R01CA82729/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (Adipokines)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiposity/physiology
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Humans
MH  - Inflammation/blood
MH  - Male
MH  - Middle Aged
MH  - Seasons
EDAT- 2007/11/17 09:00
MHDA- 2008/05/17 09:00
CRDT- 2007/11/17 09:00
PHST- 2007/11/17 09:00 [pubmed]
PHST- 2008/05/17 09:00 [medline]
PHST- 2007/11/17 09:00 [entrez]
AID - 16/11/2464 [pii]
AID - 10.1158/1055-9965.EPI-07-0374 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2464-70. doi: 
      10.1158/1055-9965.EPI-07-0374.