PMID- 18007557
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20161124
IS  - 1665-2681 (Print)
IS  - 1665-2681 (Linking)
VI  - 6
IP  - 4
DP  - 2007 Oct-Dec
TI  - New role of antinutritional factors, phytic acid and catechin in the treatment of 
      CCl4 intoxication.
PG  - 262-6
AB  - Both phytic acid (PA) and catechin (CA) are well known antioxidants of natural 
      origin. They were frequently tried on experimental level as hepatoprotectants, 
      relying only on their antioxidant properties. The present study was conducted 
      mainly to outline the other biochemical pathways underlying the hepatotherapeutic 
      potential of both drugs and to check a possible synergistic action if prescribed 
      concomitantly. As both materials are frequently taken on a daily basis in food 
      and drinks, it will be helpful to pursue their possible utility and/or to check 
      if their value is really of medical importance. For this purpose, CCl(4) was used 
      as a hepatotoxin, we evaluated plasma total sialic acid (TSA), serum ascorbic 
      acid (AA) levels, liver tissue thiobarbituric acid reactive species (TBARS) as a 
      marker for lipid peroxidation and total protein (TP) content as a rough marker to 
      measure hepatic synthetic capability in 80 male Wistar rats as experimental 
      models. Animals were classified into 8 groups (10 rats each), the first as 
      control, the second as PA treated (0.3 mg kg (-1)), orally, the third as CA 
      treated (30 mg kg (-1)) intraperitoneally, the fourth given both drugs, as a 
      single daily dose for 2 weeks. The same design was repeated 24 hours after 
      CCl(4)-intoxication (1mL kg (-1)), intraperitoneally, as a single dose. The 
      results revealed that both PA and CA when used individually, significantly 
      down-regulated TSA in both physiologic (no CCl(4 )treatment) and pathologic 
      (CCl(4)- intoxication) states accompanied by significant decrease in 
      lipoperoxidation. The therapeutic action against TSA and the antioxidant power 
      were abolished by co-administration of both drugs . AA was only decreased by PA 
      and the combination in the physiologic state. Both PA and CA showed significant 
      therapeutic effect for protein synthesis against CCl(4)-intoxication, but the 
      combination abolished this effect. We conclude that both drugs can be considered 
      as a chemotherapeutic against hepatopathies and we for the first time 
      contraindicate the concomitant use of both drugs.
FAU - Abdel-Hamid, N M
AU  - Abdel-Hamid NM
AD  - Department of Biochemistry, College of Pharmacy, Minia University, Egypt. 
      nabilmohie@yahoo.com
FAU - Faddah, L M
AU  - Faddah LM
FAU - Al-Rehany, M A
AU  - Al-Rehany MA
FAU - Ali, A H
AU  - Ali AH
FAU - Bakeet, A A
AU  - Bakeet AA
LA  - eng
PT  - Journal Article
PL  - Mexico
TA  - Ann Hepatol
JT  - Annals of hepatology
JID - 101155885
RN  - 0 (Antioxidants)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 7IGF0S7R8I (Phytic Acid)
RN  - 8R1V1STN48 (Catechin)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/therapeutic use
MH  - Ascorbic Acid/blood
MH  - Carbon Tetrachloride/*toxicity
MH  - Catechin/*therapeutic use
MH  - Chemical and Drug Induced Liver Injury
MH  - Liver/metabolism
MH  - Liver Diseases/blood/*drug therapy
MH  - Male
MH  - N-Acetylneuraminic Acid/blood
MH  - Phytic Acid/*therapeutic use
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Thiobarbituric Acid Reactive Substances/*analysis
EDAT- 2007/11/17 09:00
MHDA- 2008/02/15 09:00
CRDT- 2007/11/17 09:00
PHST- 2007/11/17 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/11/17 09:00 [entrez]
AID - 534319 [pii]
PST - ppublish
SO  - Ann Hepatol. 2007 Oct-Dec;6(4):262-6.