PMID- 18007983
OWN - NLM
STAT- MEDLINE
DCOM- 20080117
LR  - 20211020
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 115
IP  - 11
DP  - 2007 Nov
TI  - HLA-B*1301 as a biomarker for genetic susceptibility to hypersensitivity 
      dermatitis induced by trichloroethylene among workers in China.
PG  - 1553-6
AB  - BACKGROUND: Trichloroethylene (TCE) is used extensively as an industrial solvent 
      and has been recognized as one of the major environmental pollutants. To date, > 
      200 cases of TCE-induced hypersensitivity dermatitis among exposed workers have 
      been reported worldwide, and TCE exposure has become one of the critical 
      occupational health issues in Asia. OBJECTIVES: The study aimed to identify 
      genetic susceptible biomarkers associated with the TCE-induced hypersensitivity 
      dermatitis in genes located in the human leukocyte antigen (HLA) region. METHODS: 
      From 1998 to 2006, 121 cases with TCE-induced hypersensitivity dermatitis and 142 
      tolerant controls were recruited into the population-based case-control study. We 
      determined HLA alleles B, DRB1, DQA1, and DQB1, by sequence-based typing. 
      p-Values were corrected for comparisons of multiple HLA alleles. In addition, we 
      compared and analyzed the structure character of amino acid residues of HLA 
      molecules found in participants. RESULTS: We obtained complete genotyping data of 
      113 cases and 142 controls. The allele HLA-B*1301 was present in 83 (73.5%) of 
      113 patients compared with 13 (9.2%) of 142 tolerant workers (odds ratio = 27.5; 
      95% confidence interval, 13.5-55.7; corrected p = 1.48 x 10(-21)). In addition, 
      the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in 
      TCE-tolerant workers. Residue 95 shared by HLA-B*1301 and HLA-B*44 molecules 
      formed a different pocket F than other residues. CONCLUSIONS: The allele 
      HLA-B*1301 is strongly associated with TCE-induced hypersensitivity dermatitis 
      among exposed workers and might be used as a biomarker to predict high risk 
      individuals to TCE.
FAU - Li, Haishan
AU  - Li H
AD  - Key Laboratory, National Institute for Occupational Health and Poison Control, 
      Chinese Center for Disease Control and Prevention, Beijing, China.
FAU - Dai, Yufei
AU  - Dai Y
FAU - Huang, Hanlin
AU  - Huang H
FAU - Li, Laiyu
AU  - Li L
FAU - Leng, Shuguang
AU  - Leng S
FAU - Cheng, Juan
AU  - Cheng J
FAU - Niu, Yong
AU  - Niu Y
FAU - Duan, Huawei
AU  - Duan H
FAU - Liu, Qingjun
AU  - Liu Q
FAU - Zhang, Xing
AU  - Zhang X
FAU - Huang, Xianqing
AU  - Huang X
FAU - Xie, Jinxin
AU  - Xie J
FAU - Feng, Zhiming
AU  - Feng Z
FAU - Wang, Juncai
AU  - Wang J
FAU - He, Jiaxi
AU  - He J
FAU - Zheng, Yuxin
AU  - Zheng Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (HLA-B Antigens)
RN  - 290YE8AR51 (Trichloroethylene)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - China
MH  - Dermatitis/etiology/*genetics
MH  - Drug Hypersensitivity/etiology/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens/chemistry/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Models, Molecular
MH  - *Occupational Exposure
MH  - Polymorphism, Genetic
MH  - Trichloroethylene/*adverse effects
PMC - PMC2072824
OTO - NOTNLM
OT  - biomarkers
OT  - genetic polymorphism
OT  - human leukocyte antigen
OT  - hypersensitivity dermatitis
OT  - trichloroethylene
EDAT- 2007/11/17 09:00
MHDA- 2008/01/18 09:00
PMCR- 2007/11/01
CRDT- 2007/11/17 09:00
PHST- 2007/04/03 00:00 [received]
PHST- 2007/08/24 00:00 [accepted]
PHST- 2007/11/17 09:00 [pubmed]
PHST- 2008/01/18 09:00 [medline]
PHST- 2007/11/17 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - ehp0115-001553 [pii]
AID - 10.1289/ehp.10325 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2007 Nov;115(11):1553-6. doi: 10.1289/ehp.10325.