PMID- 1800801
OWN - NLM
STAT- MEDLINE
DCOM- 19920420
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 57
IP  - 1
DP  - 1991 Sep
TI  - Differential sensitization to ambulation-increasing effect of methamphetamine 
      after repeated administration to mice in activity cages of different sizes.
PG  - 91-7
AB  - We have demonstrated that repeated administration of methamphetamine (MAP) 1-2 
      mg/kg, s.c. in a tilting-type round activity cage with a diameter of 20 cm (20 
      cm-cage) at 1-7 day intervals produces progressive enhancement of the 
      ambulation-increasing effect (AIE), showing sensitization (reverse tolerance) in 
      mice. However, almost no sensitization was observed when mice had been pretreated 
      with the same doses of MAP but confined in a narrow environment repeatedly. In 
      this experiment, changes in the sensitization were investigated in mice after 
      repeated pretreatments with MAP at 2 mg/kg at 3-4 day interval for 4 times in 
      activity cages of 5 different sizes (5, 10, 15, 30 and 40 cm in diameter) in 
      comparison with that of in the 20 cm-cage. AIE obtained after MAP in the 5- and 
      10-cm cages was not enhanced, whereas AIE was significantly enhanced in the cages 
      of more than 15 cm in diameter. There was no significant difference in the 
      enhanced AIE among the 4 groups that received the same pretreatment repeatedly in 
      the cages of 15, 20, 30 and 40 cm in diameter. The present results suggest that 
      in accordance with the all-or-none law, development of the sensitization is 
      affected by the size of the activity cage in which the animals have repeatedly 
      experienced the acute drug effect.
FAU - Hirabayasi, M
AU  - Hirabayasi M
AD  - Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, 
      Japan.
FAU - Saito, T
AU  - Saito T
FAU - Tadokoro, S
AU  - Tadokoro S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Drug Administration Schedule
MH  - Male
MH  - Methamphetamine/*administration & dosage/pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/*drug effects
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 10.1254/jjp.57.91 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1991 Sep;57(1):91-7. doi: 10.1254/jjp.57.91.