PMID- 18020970
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 45
IP  - 12
DP  - 2007
TI  - Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular 
      disease.
PG  - 1652-9
AB  - Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for 
      cardiovascular disease (CVD) and the underlying mechanism is unclear. We and 
      others have reported that homocysteine (Hcy) is inversely correlated with plasma 
      high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apoA-I) in 
      patients with coronary heart disease (CHD). We confirmed this negative 
      correlation in mice with targeted deletions of the genes for apolipoprotein E 
      (apoE) and cystathionine beta-synthase (CBS). Severe HHcy (plasma Hcy 210 
      micromol/L) accelerates spontaneous arthrosclerosis in the CBS(-/-)/apoE(-/-) 
      mice, reduces the concentration of circulating HDL, apoA-I, and large HDL 
      particles, inhibits HDL function, and enhances HDL-C clearance. We have 
      demonstrated further that Hcy (0.5-2 mmol/L) reduces apoA-I protein synthesis and 
      secretion, but not RNA transcription in mouse primary hepatocytes. A different 
      mechanism was proposed based on studies using the HepG2 cells showing that Hcy 
      (5-10 mmol/L) inhibits apoA-I transcription via peroxisome proliferator-activated 
      receptor-alpha (PPARalpha)-inhibition-dependent and -independent mechanisms. 
      These studies suggest that Hcy-induced HDL-C and apoA-I inhibition represent a 
      novel mechanism by which Hcy induces atherosclerotic CVD.
FAU - Liao, Dan
AU  - Liao D
AD  - Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
FAU - Yang, Xiaofeng
AU  - Yang X
FAU - Wang, Hong
AU  - Wang H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Receptors, Scavenger)
SB  - IM
MH  - Apolipoprotein A-I/genetics
MH  - Cardiovascular Diseases/complications/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*metabolism
MH  - Lipoproteins, HDL/*metabolism
MH  - Protein Biosynthesis
MH  - Receptors, Scavenger/metabolism
RF  - 69
EDAT- 2007/11/21 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - 10.1515/CCLM.2007.358 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2007;45(12):1652-9. doi: 10.1515/CCLM.2007.358.