PMID- 18021756
OWN - NLM
STAT- MEDLINE
DCOM- 20080602
LR  - 20071224
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1188
DP  - 2008 Jan 10
TI  - Effect of a neuroprotective exercise protocol on oxidative state and BDNF levels 
      in the rat hippocampus.
PG  - 182-8
AB  - Daily moderate intensity exercise (2 weeks of 20 min/day of treadmill training), 
      which reduces damage to hippocampal slices from rats submitted to in vitro 
      ischemia, did not modify oxidative stress parameters in the hippocampus nor the 
      brain-derived neurotrophic factor (BDNF) levels in different brain regions. The 
      aim was to investigate whether the modulation of hippocampal oxidative status 
      and/or brain BDNF content is involved in exercise-induced neuroprotection. Wistar 
      rats were submitted to daily exercise in the treadmill and were sacrificed 
      approximately 16 h after the last treadmill running. Some several oxidative 
      stress parameters were determined, specifically the free radical levels, the 
      macromolecule damage, the total reactive antioxidant potential and reactivity 
      levels, which represent the total antioxidant capacity, in the hippocampus. In 
      addition, BDNF levels in different rat cerebral regions (hippocampus, cortex, 
      striatum, and the cerebellum) were measured by ELISA. The used exercise protocol 
      did not affect any oxidative stress parameters studied in the hippocampus, 
      suggesting that it does not cause a significant oxidative stress nor induce 
      adaptations of the cellular antioxidant system. Treadmill training also did not 
      change the BDNF content in brain areas studied. Considering the fact that this 
      exercise protocol have been shown to be neuroprotective, we might speculate that 
      BDNF levels and oxidative status may not be directly involved with the mechanisms 
      of exercise-induced neuroprotection after ischemia.
FAU - Cechetti, Fernanda
AU  - Cechetti F
AD  - Programa de Pos Graduacao em Ciencias Biologicas-Neurociencias, Universidade 
      Federal do Rio Grande do Sul, Rua Sarmento Leite, Porto Alegre, RS, Brazil.
FAU - Fochesatto, Cintia
AU  - Fochesatto C
FAU - Scopel, Denise
AU  - Scopel D
FAU - Nardin, Patricia
AU  - Nardin P
FAU - Goncalves, Carlos Alberto
AU  - Goncalves CA
FAU - Netto, Carlos Alexandre
AU  - Netto CA
FAU - Siqueira, Ionara Rodrigues
AU  - Siqueira IR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071017
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Free Radicals)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain/anatomy & histology/metabolism
MH  - Brain Ischemia/*metabolism/physiopathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cytoprotection/physiology
MH  - Exercise Test
MH  - Exercise Therapy/methods
MH  - Free Radicals/metabolism
MH  - Hippocampus/blood supply/*metabolism/physiopathology
MH  - Male
MH  - Organ Culture Techniques
MH  - Oxidation-Reduction
MH  - Oxidative Stress/*physiology
MH  - Oxygen Consumption
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Treatment Outcome
EDAT- 2007/11/21 09:00
MHDA- 2008/06/03 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/06/21 00:00 [received]
PHST- 2007/10/09 00:00 [revised]
PHST- 2007/10/10 00:00 [accepted]
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/06/03 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - S0006-8993(07)02460-2 [pii]
AID - 10.1016/j.brainres.2007.10.012 [doi]
PST - ppublish
SO  - Brain Res. 2008 Jan 10;1188:182-8. doi: 10.1016/j.brainres.2007.10.012. Epub 2007 
      Oct 17.