PMID- 18022309
OWN - NLM
STAT- MEDLINE
DCOM- 20080229
LR  - 20181201
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 243
IP  - 1-2
DP  - 2008 Jan 14
TI  - Pentoxifylline prevents the meglumine antimonate-induced renal toxicity in rats, 
      but not that induced by the inorganic antimony pentachloride.
PG  - 66-74
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a mediator of inflammation and has an 
      important role in human and experimental renal diseases. Pentoxifylline (PTX) has 
      been shown to inhibit cytokine synthesis, including TNF-alpha. The aim of the 
      present study was to examine the effect of PTX on meglumine antimonate (Sb(V)) 
      and antimony pentachloride (SbCl(5))-induced renal toxicity in rats. Sixty Wistar 
      rats were divided into six groups according to the treatment employed over the 
      period of 7 days: group I-saline (NaCl 0.9%); group II-PTX plus saline; group 
      III-meglumine antimonate (Sb(V)) plus saline; group IV-meglumine antimonate 
      (Sb(V)) plus PTX; group V-SbCl(5) plus saline; group VI-SbCl(5) with PTX. The 
      animals' urinary concentration ability was evaluated before and after the end of 
      the treatment. Urine and blood osmolality, sodium and creatinine concentration, 
      and urine volume per minute (V) were determined. Creatinine clearance (CrCl), 
      fractional sodium excretion (FE(Na)), and urine to plasma osmolality ratio (U/P 
      osm) were calculated. TNF-alpha concentration in blood was assessed. On the 
      seventh day, the animals were sacrificed and their kidneys were submitted to 
      histological analysis. The meglumine antimonate (Sb(V))-treated animals showed an 
      impaired renal capacity to concentrate urine, with low values of the ratio U/P 
      osm, reduction in CrCl, and an increment in TNF-alpha serum levels. PTX 
      associated with meglumine antimonate (Sb(V)) reduced TNF-alpha serum levels and 
      was effective in preventing renal functional alterations. Rats treated with 
      SbCl(5) showed functional and histopathologic alterations compatible with acute 
      tubular necrosis, and treatment with PTX did not prevent SbCl(5)-induced 
      nephrotoxicity. PTX was effective in preventing renal functional alterations 
      induced by meglumine antimonate (Sb(V)) in rats.
FAU - de Moura, Flavio Jose Dutra
AU  - de Moura FJ
AD  - Laboratory of Nephrology, Clinical Medicine, Faculty of Medicine, University of 
      Brasilia, 70.910-900 Brasilia, DF, Brazil.
FAU - Leal, Pushkin Pires
AU  - Leal PP
FAU - de Souza Furtado, Rogerio
AU  - de Souza Furtado R
FAU - Muniz-Junqueira, Maria Imaculada
AU  - Muniz-Junqueira MI
FAU - Veiga, Joel Paulo Russomano
AU  - Veiga JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071007
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (Chlorides)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0S9308207L (antimony pentachloride)
RN  - 6HG8UB2MUY (Meglumine)
RN  - 75G4TW236W (Meglumine Antimoniate)
RN  - 9IT35J3UV3 (Antimony)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Animals
MH  - Antimony/*toxicity
MH  - Antiprotozoal Agents/*toxicity
MH  - Chlorides/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - *Kidney Diseases/chemically induced/pathology/prevention & control
MH  - Kidney Function Tests
MH  - Leishmaniasis/drug therapy
MH  - Male
MH  - Meglumine/*toxicity
MH  - Meglumine Antimoniate
MH  - Organometallic Compounds/*toxicity
MH  - Pentoxifylline/administration & dosage/pharmacology/*therapeutic use
MH  - Phosphodiesterase Inhibitors/administration & dosage/pharmacology/*therapeutic 
      use
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
EDAT- 2007/11/21 09:00
MHDA- 2008/03/01 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/06/24 00:00 [received]
PHST- 2007/09/06 00:00 [revised]
PHST- 2007/09/24 00:00 [accepted]
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/03/01 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - S0300-483X(07)00669-5 [pii]
AID - 10.1016/j.tox.2007.09.032 [doi]
PST - ppublish
SO  - Toxicology. 2008 Jan 14;243(1-2):66-74. doi: 10.1016/j.tox.2007.09.032. Epub 2007 
      Oct 7.