PMID- 18022570
OWN - NLM
STAT- MEDLINE
DCOM- 20080108
LR  - 20111117
IS  - 1083-8791 (Print)
IS  - 1083-8791 (Linking)
VI  - 13
IP  - 12
DP  - 2007 Dec
TI  - HLA-DRB1*09 is associated with increased incidence of cytomegalovirus infection 
      and disease after allogeneic hematopoietic stem cell transplantation.
PG  - 1417-21
AB  - Cytomegalovirus (CMV) infection is a major complication after allogeneic 
      hematopoietic stem cell transplantation (allo-HSCT); however, we have little 
      information on the clinical association of various human leukocyte antigen (HLA) 
      alleles with CMV infection. We reviewed medical records of 60 patients who 
      underwent allo-HSCT. The effect of the 7 most frequent HLA alleles on the 
      incidence of CMV infection and disease was analyzed, including HLA-A*02, A*11, 
      A*24, B*13, B*40(60), DRB1*15, and DRB1*09. All the patients were monitored for 
      CMV infection at least once weekly within 3 months. CMV infection was found in 38 
      (63.3%) patients on a median of day 36 (range: 16-89). Diagnosis of CMV disease 
      was established in 6 (10.0%) patients, comprising pneumonia (n = 2), 
      enterocolitis (n = 2), and hemorrhagic cystitis (n = 2). CMV disease was 
      successfully treated using ganciclovir or foscarnet combined with immune 
      globulins in 4 patients. The other 2 patients died without improvement of CMV 
      disease. In multivariate analysis, grade II-IV acute graft-versus-host disease 
      (aGVHD), CMV seronegative donors, and HLA-DRB1*09 were associated with increased 
      incidence of CMV infection and disease after allo-HSCT. We suggest that more 
      cautions should be taken to prevent CMV infection in patients with HLA-DRB1*09 
      after allo-HSCT.
FAU - Du, Jinwei
AU  - Du J
AD  - Department of Hematology, Peking University First Hospital, Beijing, People's 
      Republic of China.
FAU - Liu, Jing
AU  - Liu J
FAU - Gu, Jiangying
AU  - Gu J
FAU - Zhu, Ping
AU  - Zhu P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus Infections/epidemiology/*immunology
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Graft vs Host Disease/complications/virology
MH  - HLA-DR Antigens/*immunology
MH  - HLA-DRB1 Chains
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Transplantation, Homologous/adverse effects
EDAT- 2007/11/21 09:00
MHDA- 2008/01/09 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/07/16 00:00 [received]
PHST- 2007/09/07 00:00 [accepted]
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/01/09 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - S1083-8791(07)00451-X [pii]
AID - 10.1016/j.bbmt.2007.09.003 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2007 Dec;13(12):1417-21. doi: 
      10.1016/j.bbmt.2007.09.003.