PMID- 1802340
OWN - NLM
STAT- MEDLINE
DCOM- 19920424
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 561
IP  - 2
DP  - 1991 Oct 11
TI  - Non-peptide angiotensin II receptor antagonist and angiotensin-converting enzyme 
      inhibitor: effect on a renin-induced deficit of a passive avoidance response in 
      rats.
PG  - 230-5
AB  - Non-peptide receptor ligands with differential affinity for the angiotensin II-1 
      (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an 
      angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the 
      ability to protect against a renin-induced performance deficit in a passive 
      avoidance (PA) task in rats. The ability to retain a PA response was shown to 
      decrease as the dose of intracerebroventricularly (i.c.v.) administered renin 
      increased with maximal retention deficits occurring at 1.0 micrograms/5 
      microliters i.c.v. EXP3312 (1-100 micrograms/5 microliters i.c.v.) and EXP3880 
      (1-100 micrograms/5 microliters i.c.v.) produced dose-dependent increases in 
      retention latencies when co-administered with renin. The peak effect dose (PED) 
      for EXP3312 and EXP3880 was 3 and 30 micrograms i.c.v., respectively. In 
      contrast, PD123177 was not effective in preventing the renin-induced decrease in 
      retention across a broad range of doses (0.1-100 micrograms/5 microliters 
      i.c.v.). Captopril (1-100 micrograms/5 microliters i.c.v.) also prevented the 
      renin-induced performance deficit with a PED of 30 micrograms/5 microliters 
      i.c.v. These results suggest that renin given i.c.v. produces a deficit in 
      performance of a PA response in rats and that this effect can be attenuated by an 
      ACE inhibitor, AII-1 receptor ligands, but not AII-2 receptor blocker.
FAU - DeNoble, V J
AU  - DeNoble VJ
AD  - Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0400.
FAU - DeNoble, K F
AU  - DeNoble KF
FAU - Spencer, K R
AU  - Spencer KR
FAU - Chiu, A T
AU  - Chiu AT
FAU - Wong, P C
AU  - Wong PC
FAU - Timmermans, P B
AU  - Timmermans PB
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Imidazoles)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Tetrazoles)
RN  - 11128-99-7 (Angiotensin II)
RN  - 114785-12-5 (PD 123177)
RN  - 114798-35-5 (EXP3312)
RN  - 138330-11-7 (EXP3880)
RN  - 9G64RSX1XD (Captopril)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin II/*metabolism
MH  - *Angiotensin Receptor Antagonists
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Biphenyl Compounds/administration & dosage/*pharmacology
MH  - Captopril/administration & dosage/*pharmacology
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Imidazoles/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Pyridines/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Angiotensin/physiology
MH  - Reference Values
MH  - Renin/administration & dosage/*pharmacology
MH  - Tetrazoles/administration & dosage/*pharmacology
MH  - Time Factors
EDAT- 1991/10/11 00:00
MHDA- 1991/10/11 00:01
CRDT- 1991/10/11 00:00
PHST- 1991/10/11 00:00 [pubmed]
PHST- 1991/10/11 00:01 [medline]
PHST- 1991/10/11 00:00 [entrez]
AID - 0006-8993(91)91599-V [pii]
AID - 10.1016/0006-8993(91)91599-v [doi]
PST - ppublish
SO  - Brain Res. 1991 Oct 11;561(2):230-5. doi: 10.1016/0006-8993(91)91599-v.