PMID- 18025129
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20211020
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 204
IP  - 12
DP  - 2007 Nov 26
TI  - Differential natural killer cell-mediated inhibition of HIV-1 replication based 
      on distinct KIR/HLA subtypes.
PG  - 3027-36
AB  - Decline of peak viremia during acute HIV-1 infection occurs before the 
      development of vigorous adaptive immunity, and the level of decline correlates 
      inversely with the rate of AIDS progression, implicating a potential role for the 
      innate immune response in determining disease outcome. The combined expression of 
      an activating natural killer (NK) cell receptor, the killer immunoglobulin-like 
      receptor (KIR) 3DS1, and its presumed ligand, human leukocyte antigen (HLA)-B 
      Bw4-80I, has been associated in epidemiological studies with a slow progression 
      to AIDS. We examined the functional ability of NK cells to differentially control 
      HIV-1 replication in vitro based on their KIR and HLA types. NK cells expressing 
      KIR3DS1 showed strong, significant dose- and cell contact-dependent inhibition of 
      HIV-1 replication in target cells expressing HLA-B Bw4-80I compared with NK cells 
      that did not express KIR3DS1. Furthermore, KIR3DS1+ NK cells and NKLs were 
      preferentially activated, and lysed HIV-1 infected target cells in an HLA-B 
      Bw4-80I-dependent manner. These data provide the first functional evidence that 
      variation at the KIR locus influences the effectiveness of NK cell activity in 
      the containment of viral replication.
FAU - Alter, Galit
AU  - Alter G
AD  - Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General 
      Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA.
FAU - Martin, Maureen P
AU  - Martin MP
FAU - Teigen, Nickolas
AU  - Teigen N
FAU - Carr, William H
AU  - Carr WH
FAU - Suscovich, Todd J
AU  - Suscovich TJ
FAU - Schneidewind, Arne
AU  - Schneidewind A
FAU - Streeck, Hendrik
AU  - Streeck H
FAU - Waring, Michael
AU  - Waring M
FAU - Meier, Angela
AU  - Meier A
FAU - Brander, Christian
AU  - Brander C
FAU - Lifson, Jeffrey D
AU  - Lifson JD
FAU - Allen, Todd M
AU  - Allen TM
FAU - Carrington, Mary
AU  - Carrington M
FAU - Altfeld, Marcus
AU  - Altfeld M
LA  - eng
GR  - R01-A1067031/PHS HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - N01-CO-12400/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20071119
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/immunology/*virology
MH  - HIV Infections/*immunology
MH  - HIV-1/*physiology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology/*virology
MH  - Kinetics
MH  - Receptors, KIR/*genetics/*immunology
MH  - Virus Replication/*physiology
PMC - PMC2118524
EDAT- 2007/11/21 09:00
MHDA- 2007/12/15 09:00
PMCR- 2008/05/26
CRDT- 2007/11/21 09:00
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
PHST- 2008/05/26 00:00 [pmc-release]
AID - jem.20070695 [pii]
AID - 20070695 [pii]
AID - 10.1084/jem.20070695 [doi]
PST - ppublish
SO  - J Exp Med. 2007 Nov 26;204(12):3027-36. doi: 10.1084/jem.20070695. Epub 2007 Nov 
      19.