PMID- 18025130
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20211020
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 204
IP  - 12
DP  - 2007 Nov 26
TI  - A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated 
      functional inhibition of myelomonocytic cells.
PG  - 2813-24
AB  - Viral mutational escape can reduce or abrogate recognition by the T cell receptor 
      (TCR) of virus-specific CD8+ T cells. However, very little is known about the 
      impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between 
      peptide-major histocompatibility complex (MHC) class I complexes and MHC class I 
      receptors expressed on other cell types. Here, we analyzed a variant of the 
      immunodominant human leukocyte antigen (HLA)-B2705-restricted HIV-1 Gag KK10 
      epitope (KRWIILGLNK) with an L to M amino acid substitution at position 6 (L6M), 
      which arises as a CTL escape variant after primary infection but is sufficiently 
      immunogenic to elicit a secondary, de novo HIV-1-specific CD8+ T cell response 
      with an alternative TCR repertoire in chronic infection. In addition to altering 
      recognition by HIV-1-specific CD8+ T cells, the HLA-B2705-KK10 L6M complex also 
      exhibits substantially increased binding to the immunoglobulin-like transcript 
      (ILT) receptor 4, an inhibitory MHC class I-specific receptor expressed on 
      myelomonocytic cells. Binding of the B2705-KK10 L6M complex to ILT4 leads to a 
      tolerogenic phenotype of myelomonocytic cells with lower surface expression of 
      dendritic cell (DC) maturation markers and co-stimulatory molecules. These data 
      suggest a link between CTL-driven mutational escape, altered recognition by 
      innate MHC class I receptors on myelomonocytic cells, and functional impairment 
      of DCs, and thus provide important new insight into biological consequences of 
      viral sequence diversification.
FAU - Lichterfeld, Mathias
AU  - Lichterfeld M
AD  - Partners AIDS Research Center, Massachusetts General Hospital, and Harvard 
      University Center for AIDS Research, Boston, MA 02129, USA.
FAU - Kavanagh, Daniel G
AU  - Kavanagh DG
FAU - Williams, Katie L
AU  - Williams KL
FAU - Moza, Beenu
AU  - Moza B
FAU - Mui, Stanley K
AU  - Mui SK
FAU - Miura, ToshiYuki
AU  - Miura T
FAU - Sivamurthy, Rohini
AU  - Sivamurthy R
FAU - Allgaier, Rachel
AU  - Allgaier R
FAU - Pereyra, Florencia
AU  - Pereyra F
FAU - Trocha, Alicja
AU  - Trocha A
FAU - Feeney, Margaret
AU  - Feeney M
FAU - Gandhi, Rajesh T
AU  - Gandhi RT
FAU - Rosenberg, Eric S
AU  - Rosenberg ES
FAU - Altfeld, Marcus
AU  - Altfeld M
FAU - Allen, Todd M
AU  - Allen TM
FAU - Allen, Rachel
AU  - Allen R
FAU - Walker, Bruce D
AU  - Walker BD
FAU - Sundberg, Eric J
AU  - Sundberg EJ
FAU - Yu, Xu G
AU  - Yu XG
LA  - eng
GR  - F32 AI058457/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071119
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
CIN - J Exp Med. 2007 Nov 26;204(12):2785-8. PMID: 18025124
MH  - Acquired Immunodeficiency Syndrome/genetics/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology/*virology
MH  - HIV/genetics/*immunology
MH  - HIV Infections/*immunology
MH  - HLA-B27 Antigen/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Humans
MH  - Monocytes/*immunology/virology
MH  - Mutation
MH  - Myeloid Cells/*immunology/virology
MH  - Receptors, Antigen, T-Cell/genetics
MH  - T-Lymphocytes, Cytotoxic/*immunology/*virology
PMC - PMC2118510
EDAT- 2007/11/21 09:00
MHDA- 2007/12/15 09:00
PMCR- 2008/05/26
CRDT- 2007/11/21 09:00
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
PHST- 2008/05/26 00:00 [pmc-release]
AID - jem.20061865 [pii]
AID - 20061865 [pii]
AID - 10.1084/jem.20061865 [doi]
PST - ppublish
SO  - J Exp Med. 2007 Nov 26;204(12):2813-24. doi: 10.1084/jem.20061865. Epub 2007 Nov 
      19.