PMID- 18025886
OWN - NLM
STAT- MEDLINE
DCOM- 20080116
LR  - 20071120
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 21
IP  - 18
DP  - 2007 Nov 30
TI  - Personal and community benefits and harms of research: views from Rakai, Uganda.
PG  - 2493-501
AB  - OBJECTIVES: To assess what individuals in low-income countries perceive as 
      benefits and harms of population-based HIV/STD research. DESIGN: A total of 811 
      research participants, research decliners, and community opinion leaders in the 
      Rakai District, Uganda were surveyed. Types of personal and community benefits 
      and harms, as well as rates of reporting great personal and community benefit 
      were assessed. METHODS: Using logistic regression, demographic characteristics, 
      participant and opinion leader status, use of Rakai Health Sciences Program 
      (RHSP) services, and perceived research effects were entered as predictors of 
      reported great personal and great community benefit. RESULTS: Most respondents 
      thought that RHSP research was of great personal (85%) and community (88%) 
      benefit. The perception that the RHSP was a great personal benefit was correlated 
      with female sex, post-secondary education, frequent use of RHSP-sponsored medical 
      services, health knowledge gains, and increased hope for future health 
      improvements. Persons of non-Baganda ethnicity and 30-39 year-olds were less 
      likely to believe research was personally beneficial. Regarding research as a 
      great community benefit was associated with reported health knowledge gains, 
      greater hope for Rakai residents' future health, and local economic benefit. 
      Decliners were the most likely to report a personal harm, while community opinion 
      leaders identified community harms at the highest rates. CONCLUSIONS: The 
      majority of Rakai residents report that HIV/STD research has enhanced their own 
      and their communities' welfare. Different factors were associated with the belief 
      that research is a personal versus community benefit. Variations in participant, 
      decliner, and community opinion leader perceptions highlight inadequacies of 
      current community consultation mechanisms.
FAU - Thiessen, Carrie
AU  - Thiessen C
AD  - Department of Clinical Bioethics, National Institutes of Health, Bethesda, 
      Maryland, USA.
FAU - Ssekubugu, Robert
AU  - Ssekubugu R
FAU - Wagman, Jennifer
AU  - Wagman J
FAU - Kiddugavu, Mohammed
AU  - Kiddugavu M
FAU - Wawer, Maria J
AU  - Wawer MJ
FAU - Emanuel, Ezekiel
AU  - Emanuel E
FAU - Gray, Ronald
AU  - Gray R
FAU - Serwadda, David
AU  - Serwadda D
FAU - Grady, Christine
AU  - Grady C
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
SB  - IM
MH  - Adult
MH  - *Attitude to Health
MH  - *Developing Countries
MH  - Ethics, Research
MH  - Female
MH  - HIV Infections/*psychology/therapy
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Refusal to Participate/psychology
MH  - Research Subjects/psychology
MH  - Risk Assessment
MH  - Sexually Transmitted Diseases/psychology
MH  - Socioeconomic Factors
MH  - Therapeutic Human Experimentation/*ethics
MH  - Uganda
EDAT- 2007/11/21 09:00
MHDA- 2008/01/17 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/01/17 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - 00002030-200711300-00015 [pii]
AID - 10.1097/QAD.0b013e3282f029d3 [doi]
PST - ppublish
SO  - AIDS. 2007 Nov 30;21(18):2493-501. doi: 10.1097/QAD.0b013e3282f029d3.