PMID- 18025948
OWN - NLM
STAT- MEDLINE
DCOM- 20080320
LR  - 20211110
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 118
IP  - 2
DP  - 2008 Feb
TI  - Hoarseness: is it really laryngopharyngeal reflux?
PG  - 363-6
AB  - OBJECTIVE/HYPOTHESIS: This study will test the hypothesis that proton pump 
      inhibitor (PPI) use is prevalent among patients referred for hoarseness and will 
      assess the ultimate diagnosis and factors associated with patients' voice 
      outcomes. STUDY DESIGN: Retrospective review of patients in a tertiary care voice 
      clinic. METHODS: Patients with a primary diagnosis of hoarseness, who were taking 
      or had taken PPIs in the previous 2 months and referred to a tertiary care voice 
      clinic, were identified. The dosage and length of PPI administration, patient 
      report of gastroesophageal reflux (GER), presence of findings suggesting muscle 
      tension dysphonia (MTD), patient demographics, diagnosis, chronicity of symptoms, 
      interventions, follow-up, and outcome were determined. RESULTS: Of 299 patients, 
      264 met the inclusion criteria. The mean age was 47.2 years, with a range of 18 
      to 89 years, with 26.7% male and 73.3% female. Among patients referred for voice 
      problems, 148 (56.1%) had previously tried PPIs or were currently on PPI 
      treatment; 44 (29.7%) stopped taking their PPI because of continued hoarseness, 
      and 104 (70.3%) had persistent hoarseness and associated throat complaints 
      despite continued PPI treatment. Among patients who quit taking their PPI because 
      of continued voice complaints, 79.5% did not have traditional GER symptoms of 
      heartburn or regurgitation. The most common treatment after referral was voice 
      therapy, with an overall voice therapy response rate of 62.7%. CONCLUSIONS: PPI 
      use is prevalent among patients referred because of persistent hoarseness. 
      Whether patients have GER or MTD may influence patients' voice outcomes in 
      response to PPI treatment.
FAU - Cohen, Seth M
AU  - Cohen SM
AD  - Duke Voice Care Center, Division of Otolaryngology-Head and Neck Surgery, Duke 
      University Medical Center, Durham, North Carolina 27710, USA. seth.cohen@duke.edu
FAU - Garrett, C Gaelyn
AU  - Garrett CG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gastroesophageal Reflux/*complications/diagnosis/*physiopathology
MH  - Hoarseness/diagnosis/*etiology/therapy
MH  - Humans
MH  - Hypopharynx/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Voice Quality
EDAT- 2007/11/21 09:00
MHDA- 2008/03/21 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/03/21 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - 10.1097/MLG.0b013e318158f72d [doi]
PST - ppublish
SO  - Laryngoscope. 2008 Feb;118(2):363-6. doi: 10.1097/MLG.0b013e318158f72d.