PMID- 18026177
OWN - NLM
STAT- MEDLINE
DCOM- 20080522
LR  - 20180822
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 86
IP  - 2
DP  - 2008 Feb
TI  - Normal proportion and expression of maturation markers in migratory dendritic 
      cells in the absence of germs or Toll-like receptor signaling.
PG  - 200-5
AB  - Dendritic cells (DCs) play major roles in immunosurveillance. In peripheral 
      tissues, 'immature' DCs are dedicated to capturing antigens. Detection of 
      pathogens through Toll-like receptors (TLRs) triggers DC migration to the lymph 
      nodes (LNs), where they acquire a 'mature' phenotype specialized at presenting 
      antigens. However, DCs migrate from tissues and mature even in the absence of 
      overt infections. This has been attributed to detection of commensal flora in the 
      skin, the gut or other peripheral tissues in the steady state. To test this 
      assumption, we have analyzed the DCs contained in the lymphoid organs of 
      germ-free mice and of mice lacking the TLR adapter molecules, MyD88 and TRIF. We 
      show that the proportion and expression of maturation markers in DC immigrants in 
      the LNs of these mice are similar to those in normal mice. These results suggest 
      that DC migration from tissues, followed by their phenotypic maturation, is 
      regulated in the steady state by an inherent program of DC differentiation or by 
      the release of low levels of inflammatory signals from normal tissues.
FAU - Wilson, Nicholas S
AU  - Wilson NS
AD  - The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 
      Australia.
FAU - Young, Louise J
AU  - Young LJ
FAU - Kupresanin, Fiona
AU  - Kupresanin F
FAU - Naik, Shalin H
AU  - Naik SH
FAU - Vremec, David
AU  - Vremec D
FAU - Heath, William R
AU  - Heath WR
FAU - Akira, Shizuo
AU  - Akira S
FAU - Shortman, Ken
AU  - Shortman K
FAU - Boyle, Jeff
AU  - Boyle J
FAU - Maraskovsky, Eugene
AU  - Maraskovsky E
FAU - Belz, Gabrielle T
AU  - Belz GT
FAU - Villadangos, Jose A
AU  - Villadangos JA
LA  - eng
GR  - Howard Hughes Medical Institute/United States
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071120
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (TICAM-1 protein, mouse)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Adaptor Proteins, Vesicular Transport/deficiency/immunology/metabolism
MH  - Animals
MH  - Bacteria/immunology
MH  - Cell Movement
MH  - Dendritic Cells/immunology/microbiology/*physiology
MH  - Germ-Free Life
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myeloid Differentiation Factor 88/deficiency/immunology/metabolism
MH  - Signal Transduction
MH  - Toll-Like Receptors/*immunology/metabolism
EDAT- 2007/11/21 09:00
MHDA- 2008/05/23 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/05/23 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - 7100125 [pii]
AID - 10.1038/sj.icb.7100125 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2008 Feb;86(2):200-5. doi: 10.1038/sj.icb.7100125. Epub 2007 
      Nov 20.