PMID- 18027087
OWN - NLM
STAT- MEDLINE
DCOM- 20080408
LR  - 20211020
IS  - 1380-7870 (Print)
IS  - 1380-7870 (Linking)
VI  - 13
IP  - 4
DP  - 2007 Dec
TI  - The National Wilms Tumor Study: a 40 year perspective.
PG  - 463-70
AB  - The National Wilms Tumor Study (NWTS) was the first pediatric intergroup clinical 
      research unit in North America. It was thus able to collect data concerning 
      children with malignant kidney tumors from each of the then-extant childhood 
      cancer cooperative study groups. Enough patients-about 350 per year-could thus be 
      gathered to study the nature and clinical characteristics of the various kidney 
      malignant tumors of childhood. It also enabled randomized trials of comparative 
      treatment regimens, patients stratified following stipulated risk criteria. The 
      result has been a steadily increasing two-year survival rate to the 90% level 
      while at the same time modulating the intensity of therapy according to 
      well-defined needs. For example, routine post-operative radiation therapy, 
      damaging to normal as well as neoplastic tissues, has been largely eliminated. 
      The proportion of patients given doxorubicin, a cardiotoxic drug, also has been 
      curtailed. These two therapies are now restricted to the 30% of patients who have 
      more advanced or more aggressive disease. All this has been driven to meet the 
      challenge inherent in the motto of pediatric oncology: "Cure is not enough"; that 
      is, the cured child of to-day must not become the chronically ill adult of 
      tomorrow, suffering from the delayed complications secondary to unnecessary, 
      toxic therapies.
FAU - D'Angio, Giulio J
AU  - D'Angio GJ
AD  - Radiation Oncology, Hospital of the University of Pennsylvania, Donner 2, 3400 
      Spruce Street, Philadelphia, PA 19104, USA. dangio@xrt.upenn.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20071120
PL  - United States
TA  - Lifetime Data Anal
JT  - Lifetime data analysis
JID - 9516348
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Kidney Neoplasms/pathology/*therapy
MH  - Randomized Controlled Trials as Topic/methods
MH  - Survival Analysis
MH  - Wilms Tumor/pathology/*therapy
RF  - 26
EDAT- 2007/11/21 09:00
MHDA- 2008/04/09 09:00
CRDT- 2007/11/21 09:00
PHST- 2007/09/18 00:00 [received]
PHST- 2007/09/24 00:00 [accepted]
PHST- 2007/11/21 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2007/11/21 09:00 [entrez]
AID - 10.1007/s10985-007-9062-0 [doi]
PST - ppublish
SO  - Lifetime Data Anal. 2007 Dec;13(4):463-70. doi: 10.1007/s10985-007-9062-0. Epub 
      2007 Nov 20.