PMID- 18027855
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20160303
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 122
IP  - 6
DP  - 2008 Mar 15
TI  - Fibroblast nemosis arrests growth and induces differentiation of human leukemia 
      cells.
PG  - 1243-52
AB  - Interactive signaling between cancer cells and stroma plays an important role in 
      determining tumor development. We recently found tumor cell-derived factors to 
      induce fibroblast clustering, and that the high amounts of hepatocyte growth 
      factor/scatter factor (HGF/SF) produced by these cell-cell contact-activated 
      fibroblasts enhanced the invasiveness of c-Met-expressing cancer cells. We now 
      observed that leukemia cells lacking c-Met respond to this novel type of 
      fibroblast activation, nemosis, with growth arrest and differentiation to a 
      dendritic cell-like phenotype. This effect was counteracted by introduction of 
      c-Met expression into these cells. Moreover, those leukemia cell lines harboring 
      properly processed c-Met showed no effect in response to nemosis. We propose this 
      effect to be mediated by nemosis-derived cytokine signals, and present the 
      potential candidates induced in the nemotic fibroblasts: interleukins-1, -6, -8, 
      -11, leukemia inhibitory factor and granulocyte-macrophage-colony-stimulating 
      factor. Our results emphasize the role of activated stromal fibroblasts in 
      controlling progression of certain hematologic malignancies in a c-Met 
      expression-dependent manner.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Kankuri, Esko
AU  - Kankuri E
AD  - Institute of Biomedicine, Pharmacology, University of Helsinki, Finland. 
      esko.kankuri@helsinki.fi
FAU - Babusikova, Olga
AU  - Babusikova O
FAU - Hlubinova, Kristina
AU  - Hlubinova K
FAU - Salmenpera, Pertteli
AU  - Salmenpera P
FAU - Boccaccio, Carla
AU  - Boccaccio C
FAU - Lubitz, Werner
AU  - Lubitz W
FAU - Harjula, Ari
AU  - Harjula A
FAU - Bizik, Jozef
AU  - Bizik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antigens, Surface)
RN  - 0 (Cytokines)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Antigens, Surface/immunology
MH  - Apoptosis
MH  - *Cell Differentiation
MH  - Cell Line, Tumor
MH  - Coculture Techniques
MH  - Cytokines/biosynthesis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fibroblasts/*cytology
MH  - Flow Cytometry
MH  - Humans
MH  - Leukemia/immunology/metabolism/*pathology
MH  - Proto-Oncogene Proteins c-met/metabolism
EDAT- 2007/11/22 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/11/22 09:00
PHST- 2007/11/22 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/11/22 09:00 [entrez]
AID - 10.1002/ijc.23179 [doi]
PST - ppublish
SO  - Int J Cancer. 2008 Mar 15;122(6):1243-52. doi: 10.1002/ijc.23179.