PMID- 18028272
OWN - NLM
STAT- MEDLINE
DCOM- 20080328
LR  - 20080130
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 48
IP  - 2
DP  - 2008 Feb
TI  - Establishing a cord blood banking and transplantation program in Mexico: a single 
      institution experience.
PG  - 228-36
AB  - BACKGROUND: Over the past decade, umbilical cord blood (UCB) banking and 
      transplantation have increased significantly worldwide. The experience in 
      developing countries, however, is still limited. In January 2005 the Mexican 
      Institute of Social Security (IMSS) initiated its UCB banking and transplantation 
      program. This study reports on the experience generated at this institution 
      during the first 2 years of activities. STUDY DESIGN AND METHODS: A public UCB 
      bank was established at La Raza Medical Center, IMSS, in Mexico City. Good 
      manufacturing practices and standard operating procedures were used to address 
      donor selection, as well as UCB collection, processing, and cryopreservation. 
      Based mainly on human leukocyte antigen (HLA) and total nucleated cell (TNC) 
      content, specific UCB units were thawed, processed, and released for 
      transplantation. RESULTS: Based on stringent selection criteria, 360 UCB units 
      were collected from January 2005 to December 2006. A total of 201 (56%) units 
      (minimum volume, 50 mL without anticoagulant) were processed and stored. Median 
      values for specific parameters were as follows: volume, 89.9 mL; viability, 
      94.8%; TNCs, 0.91 x 10(9); CD34+ cells, 3.13 x 10(6); and colony-forming cells, 
      1.20 x 10(6). During this period, 10 units had been released for transplantation 
      to seven patients (six children and one adult). Engraftment was observed in five 
      patients; four of them were still in remission (114-293 days after transplant). 
      In spite of showing sustained engraftment, one patient died on Day +88. Two 
      patients showed no engraftment and died 29 to 30 days after transplant. 
      CONCLUSION: The results obtained during this initial period are encouraging and 
      indicate that the UCB banking and transplantation program at IMSS will help to 
      improve already existing hematopoietic cell transplant programs in Mexico. The 
      experience generated at IMSS may be helpful to other institutions, particularly 
      those in developing countries.
FAU - Novelo-Garza, Barbara
AU  - Novelo-Garza B
AD  - Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza 
      Medical Center, IMSS, Mexico City, Mexico.
FAU - Limon-Flores, Alejandro
AU  - Limon-Flores A
FAU - Guerra-Marquez, Angel
AU  - Guerra-Marquez A
FAU - Luna-Bautista, Fernando
AU  - Luna-Bautista F
FAU - Juan-Shum, Luis
AU  - Juan-Shum L
FAU - Montero, Ines
AU  - Montero I
FAU - Sanchez-Valle, Elizabeth
AU  - Sanchez-Valle E
FAU - Velez-Ruelas, Maria Antonieta
AU  - Velez-Ruelas MA
FAU - Mayani, Hector
AU  - Mayani H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071119
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
CIN - Transfusion. 2008 Feb;48(2):207-8. PMID: 18230081
MH  - Adolescent
MH  - Adult
MH  - Blood Banks/*organization & administration
MH  - *Cord Blood Stem Cell Transplantation
MH  - *Fetal Blood/immunology
MH  - Humans
MH  - Mexico
MH  - Time Factors
EDAT- 2007/11/22 09:00
MHDA- 2008/03/29 09:00
CRDT- 2007/11/22 09:00
PHST- 2007/11/22 09:00 [pubmed]
PHST- 2008/03/29 09:00 [medline]
PHST- 2007/11/22 09:00 [entrez]
AID - TRF01529 [pii]
AID - 10.1111/j.1537-2995.2007.01529.x [doi]
PST - ppublish
SO  - Transfusion. 2008 Feb;48(2):228-36. doi: 10.1111/j.1537-2995.2007.01529.x. Epub 
      2007 Nov 19.