PMID- 18029382
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20080117
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 10
IP  - 1
DP  - 2008 Jan
TI  - Cardiac resynchronization therapy in left ventricular 
      hypertrabeculation/non-compaction and myopathy.
PG  - 59-62
AB  - AIMS: Little is known how patients with left ventricular 
      hypertrabeculation/non-compaction (LVHT) and heart failure respond to cardiac 
      resynchronization therapy (CRT). METHODS AND RESULTS: Included in this 
      retrospective study were 8/102 patients (3 female, age range 43-78 years), in 
      whom LVHT was diagnosed and in whom a CRT system was implanted. All eight 
      patients were investigated neurologically and in seven of them a myopathy was 
      found. The mean follow-up after CRT implantation was 39 (4-68) months. All 
      patients improved by one or more New York Heart Association (NYHA) classes, and 
      two by two NYHA classes. The left ventricular end-diastolic diameter decreased by 
      < or =5% in 2 patients, by 6-10% in 3 patients, by 12% in 1 patient, and by >30% 
      in 2 patients. The left ventricular systolic function, as assessed by the 
      fractional shortening, did not change in 2 patients, increased by 10% in 2 
      patients, by 59% in 1 patient, doubled in 2 patients, and showed a five-fold 
      increase in 1 patient. Two patients died during follow-up. CONCLUSION: CRT by 
      biventricular pacing in LVHT, heart failure, and myopathy leads to improvement in 
      functional capacity in all patients and improvement of systolic function in half 
      of the patients. The weak response of LVHT patients to CRT may be due to 
      inappropriate selection or comorbidities, in particular, neuromuscular disorders.
FAU - Stollberger, Claudia
AU  - Stollberger C
AD  - 2. Medizinische Abteilung, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030 
      Wien, Osterreich. claudia.stoellberger@chello.at
FAU - Blazek, Gerhard
AU  - Blazek G
FAU - Bucher, Elisabeth
AU  - Bucher E
FAU - Finsterer, Josef
AU  - Finsterer J
LA  - eng
PT  - Journal Article
DEP - 20071119
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Heart Failure/etiology/physiopathology/prevention & control
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuromuscular Diseases/complications/physiopathology/*therapy
MH  - *Pacemaker, Artificial
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/complications/physiopathology/*therapy
EDAT- 2007/11/22 09:00
MHDA- 2008/03/07 09:00
CRDT- 2007/11/22 09:00
PHST- 2007/11/22 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/11/22 09:00 [entrez]
AID - eum245 [pii]
AID - 10.1093/europace/eum245 [doi]
PST - ppublish
SO  - Europace. 2008 Jan;10(1):59-62. doi: 10.1093/europace/eum245. Epub 2007 Nov 19.