PMID- 18031723
OWN - NLM
STAT- MEDLINE
DCOM- 20080415
LR  - 20220905
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 579
IP  - 1-3
DP  - 2008 Jan 28
TI  - Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF 
      rats.
PG  - 418-25
AB  - Lithospermic acid B (LAB), an active component isolated from Salvia 
      miltiorrhizae, has been reported to have renoprotective effects in type 1 
      diabetic animal models. In the present study we investigated the effects of LAB 
      on the prevention of diabetic nephropathy in type 2 diabetic Otsuka 
      Long-Evans-Tokushima Fatty (OLETF) rats. LAB (20 mg/kg) was given orally once 
      daily to 10-week-old male OLETF rats for 28 weeks. Treatment of OLETF rats with 
      LAB had little effects on body weight and blood glucose levels. Treatment with 
      LAB resulted in significant reduction in blood pressure. LAB markedly attenuated 
      albuminuria and significantly lowered levels of lipid peroxidation, monocyte 
      chemoattractant protein-1 (MCP-1), and transforming growth factor-beta 
      (TGF-beta1) expression in renal tissues of OLETF rats. In addition, LAB inhibited 
      the progression of glomerular hypertrophy, mesangial expansion, and expansion of 
      the extracellular matrix in the renal cortex. Collectively, these results suggest 
      that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by 
      decreasing blood pressure, oxidative stress, and MCP-1 expression. Our results 
      suggest that LAB might be a new therapeutic agent for the prevention of 
      nephropathy in type 2 diabetes.
FAU - Kang, Eun Seok
AU  - Kang ES
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Geun Taek
AU  - Lee GT
FAU - Kim, Beom Seok
AU  - Kim BS
FAU - Kim, Chul Hoon
AU  - Kim CH
FAU - Seo, Gi Ho
AU  - Seo GH
FAU - Han, Seung Jin
AU  - Han SJ
FAU - Hur, Kyu Yeon
AU  - Hur KY
FAU - Ahn, Chul Woo
AU  - Ahn CW
FAU - Ha, Hunjoo
AU  - Ha H
FAU - Jung, Mankil
AU  - Jung M
FAU - Ahn, Young Soo
AU  - Ahn YS
FAU - Cha, Bong Soo
AU  - Cha BS
FAU - Lee, Hyun Chul
AU  - Lee HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071101
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Benzofurans)
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Depsides)
RN  - C1GQ844199 (salvianolic acid B)
RN  - EC 1.1.1.21 (Aldehyde Reductase)
SB  - IM
MH  - Administration, Oral
MH  - Aldehyde Reductase/*antagonists & inhibitors
MH  - Animals
MH  - Benzofurans/isolation & purification/*pharmacology
MH  - Blood Glucose/drug effects
MH  - Blood Pressure/drug effects
MH  - Chemokine CCL2/drug effects/genetics
MH  - Depsides/isolation & purification/*pharmacology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/*prevention & control
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Inbred OLETF
MH  - Rats, Long-Evans
MH  - Salvia miltiorrhiza/chemistry
EDAT- 2007/11/23 09:00
MHDA- 2008/04/16 09:00
CRDT- 2007/11/23 09:00
PHST- 2007/08/20 00:00 [received]
PHST- 2007/10/17 00:00 [revised]
PHST- 2007/10/22 00:00 [accepted]
PHST- 2007/11/23 09:00 [pubmed]
PHST- 2008/04/16 09:00 [medline]
PHST- 2007/11/23 09:00 [entrez]
AID - S0014-2999(07)01224-1 [pii]
AID - 10.1016/j.ejphar.2007.10.070 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2008 Jan 28;579(1-3):418-25. doi: 10.1016/j.ejphar.2007.10.070. 
      Epub 2007 Nov 1.